NDLI: Prevention of esophageal strictures after endoscopic submucosal dissection

Content Provider	PubMed Central
Author	Kobayashi, Shinichiro Kanai, Nobuo Ohki, Takeshi Takagi, Ryo Yamaguchi, Naoyuki Hajime, Isomoto Kasai, Yoshiyuki Hosoi, Takahiro Nakao, Kazuhiko Eguchi, Susumu Yamamoto, Masakazu Yamato, Masayuki Okano, Teruo
Copyright Year	2014
Abstract	Endoscopic mucosal resection (EMR) and endoscopic submucosal dissection (ESD) have recently been accepted as less invasive methods for treating patients with early esophageal cancers such as squamous cell carcinoma and dysplasia of Barrett’s esophagus. However, the large defects in the esophageal mucosa often cause severe esophageal strictures, which dramatically reduce the patient’s quality of life. Although preventive endoscopic balloon dilatation can reduce dysphagia and the frequency of dilatation, other approaches are necessary to prevent esophageal strictures after ESD. This review describes several strategies for preventing esophageal strictures after ESD, with a particular focus on anti-inflammatory and tissue engineering approaches. The local injection of triamcinolone acetonide and other systemic steroid therapies are frequently used to prevent esophageal strictures after ESD. Tissue engineering approaches for preventing esophageal strictures have recently been applied in basic research studies. Scaffolds with temporary stents have been applied in five cases, and this technique has been shown to be safe and is anticipated to prevent esophageal strictures. Fabricated autologous oral mucosal epithelial cell sheets to cover the defective mucosa similarly to how commercially available skin products fabricated from epidermal cells are used for skin defects or in cases of intractable ulcers. Fabricated autologous oral-mucosal-epithelial cell sheets have already been shown to be safe.
Related Links	http://dx.doi.org/10.3748/wjg.v20.i41.15098
Ending Page	15109
Page Count	12
Starting Page	15098
File Format	PDF
ISSN	22192840
e-ISSN	22192840
Journal	World Journal of Gastroenterology : WJG
Issue Number	41
Volume Number	20
Language	English
Publisher	Baishideng Publishing Group Inc
Publisher Date	2014-11-07
Access Restriction	Open
Rights Holder	Baishideng Publishing Group Inc
Subject Keyword	Research in Higher Education
Content Type	Text
Resource Type	Article

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