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| Content Provider | PubMed Central |
|---|---|
| Author | Chang, George T. Moulder, James W. |
| Abstract | Mouse fibroblasts (L cells) infected with the 6BC strain of Chlamydia psittaci released potassium ion (K+) into the extracellular milieu in a way that depended on size of inoculum and time after infection. When the multiplicity of infection was 500 to 1,000 50% infectious units (ID50) per L cell, loss of intracellular K+ was first apparent 4 to 10 h after infection and was nearly complete at 6 to 20 h. Magnesium ion and inorganic phosphate (Pi) were also released. Similar multiplicities of ultraviolet-inactivated C. psittaci also caused release of K+. Leakage of inorganic ions probably resulted from immediate damage to the host-cell plasma membrane during ingestion of large numbers of chlamydiae. With multiplicities of 1 to 50 ID50 per L cell, ingestion of C. psittaci was not by itself enough to cause release of K+ and Pi from infected L cells. There was a delay of 36 to 72 h between infection and massive leakage of intracellular ions during which time the chlamydiae multiplied extensively. Fifty ID50 of ultraviolet-inactivated C. psittaci per L cell did not bring about significant leakage of K+, even after 72 h. The mechanism whereby these multiplicities of infection destroy the ability of host cells to retain intracellular molecules is not known. HeLa 229 cells also released K+ and Pi after infection, but these losses occurred more slowly than in comparably infected L cells, possibly because C. psittaci did not multiply as extensively in HeLa cells as it did in L cells. The significance of the inability of chlamydiae-infected cells to regulate the flow of molecules through their plasma membranes is discussed. |
| Starting Page | 827 |
| File Format | |
| ISSN | 10985522 |
| e-ISSN | 10985522 |
| Journal | Infection and Immunity |
| Issue Number | 3 |
| Volume Number | 19 |
| Language | English |
| Publisher Date | 1978-03-01 |
| Access Restriction | Open |
| Subject Keyword | Research in Higher Education |
| Content Type | Text |
| Resource Type | Article |
| Subject | Infectious Diseases Parasitology Immunology Microbiology |
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