NDLI: Single molecule studies of RNA polymerase II transcription in vitro

Content Provider	PubMed Central
Author	Horn, Abigail E. Goodrich, James A. Kugel, Jennifer F.
Copyright Year	2014
Abstract	Eukaryotic mRNA transcription by RNA polymerase II (RNAP II) is the first step in gene expression and a key determinant of cellular regulation. Elucidating the mechanism by which RNAP II synthesizes RNA is therefore vital to determining how genes are controlled under diverse biological conditions. Significant advances in understanding RNAP II transcription have been achieved using classical biochemical and structural techniques; however, aspects of the transcription mechanism cannot be assessed using these approaches. The application of single-molecule techniques to study RNAP II transcription has provided new insight only obtainable by studying molecules in this complex system one at a time.
Related Links	http://dx.doi.org/10.4161/trns.27608
Starting Page	27608
File Format	PDF
ISSN	21541264
e-ISSN	21541272
Journal	Transcription
Issue Number	1
Volume Number	5
Language	English
Publisher	Landes Bioscience
Publisher Date	2014-01-01
Access Restriction	Open
Rights Holder	Landes Bioscience
Subject Keyword	Research in Higher Education
Content Type	Text
Resource Type	Article
Subject	Genetics Biochemistry Biotechnology

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Single molecule studies of RNA polymerase II transcription in vitro