NDLI: Resolving Salmonella infection reveals dynamic and persisting changes in murine bone marrow progenitor cell phenotype and function

Content Provider	PubMed Central
Author	Ross, Ewan A. Adriana, Flores-langarica Bobat, Saeeda Coughlan, Ruth E. Marshall, Jennifer L. Hitchcock, Jessica R. Cook, Charlotte N. Carvalho-gaspar, Manuela M. Mitchell, Andrea M. Clarke, Mary Garcia, Paloma Cobbold, Mark Mitchell, Tim J. Henderson, Ian R. Jones, Nick D. Anderson, Graham Buckley, Christopher D. Cunningham, Adam F.
Copyright Year	2014
Abstract	The generation of immune cells from BM precursors is a carefully regulated process. This is essential to limit the potential for oncogenesis and autoimmunity yet protect against infection. How infection modulates this is unclear. Salmonella can colonize systemic sites including the BM and spleen. This resolving infection has multiple IFN-γ-mediated acute and chronic effects on BM progenitors, and during the first week of infection IFN-γ is produced by myeloid, NK, NKT, CD4+ T cells, and some lineage-negative cells. After infection, the phenotype of BM progenitors rapidly but reversibly alters, with a peak ∼30-fold increase in Sca-1hi progenitors and a corresponding loss of Sca-1lo/int subsets. Most strikingly, the capacity of donor Sca-1hi cells to reconstitute an irradiated host is reduced; the longer donor mice are exposed to infection, and Sca-1hic-kitint cells have an increased potential to generate B1a-like cells. Thus, Salmonella can have a prolonged influence on BM progenitor functionality not directly related to bacterial persistence. These results reflect changes observed in leucopoiesis during aging and suggest that BM functionality can be modulated by life-long, periodic exposure to infection. Better understanding of this process could offer novel therapeutic opportunities to modulate BM functionality and promote healthy aging.
Related Links	http://dx.doi.org/10.1002/eji.201344350
Ending Page	2330
Page Count	13
Starting Page	2318
File Format	PDF
ISSN	00142980
e-ISSN	15214141
Journal	European Journal of Immunology
Issue Number	8
Volume Number	44
Language	English
Publisher	BlackWell Publishing Ltd
Publisher Date	2014-08-01
Access Restriction	Open
Rights Holder	BlackWell Publishing Ltd
Subject Keyword	Immunology Immunology and Allergy Research in Higher Education
Content Type	Text
Resource Type	Article
Subject	Immunology and Allergy Immunology

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4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
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