NDLI: Gastrointestinal dysfunction in liver cirrhosis

Content Provider	PubMed Central
Author	Evangelos, Kalaitzakis
Copyright Year	2014
Abstract	Patients with liver cirrhosis exhibit several features of gut dysfunction which may contribute to the development of cirrhosis complications as well as have an impact on nutritional status and health-related quality of life. Gastrointestinal symptoms are common in cirrhosis and their pathophysiology probably involves factors related to liver disease severity, psychological distress, and gut dysfunction (e.g., increased gastric sensitivity to distension and delayed gut transit). They may lead to reduced food intake and, thus, may contribute to the nutritional status deterioration in cirrhotic patients. Although tense ascites appears to have a negative impact on meal-induced accommodation of the stomach, published data on gastric accommodation in cirrhotics without significant ascites are not unanimous. Gastric emptying and small bowel transit have generally been shown to be prolonged. This may be related to disturbances in postprandial glucose, insulin, and ghrelin levels, which, in turn, appear to be associated to insulin resistance, a common finding in cirrhosis. Furthermore, small bowel manometry disturbances and delayed gut transit may be associated with the development of small bowel bacterial overgrowth. Finally, several studies have reported intestinal barrier dysfunction in patients with cirrhosis (especially those with portal hypertension), which is related to bacterial translocation and permeation of intestinal bacterial products, e.g., endotoxin and bacterial DNA, thus potentially being involved in the pathogenesis of complications of liver cirrhosis.
Related Links	http://dx.doi.org/10.3748/wjg.v20.i40.14686
Ending Page	14695
Page Count	10
Starting Page	14686
File Format	PDF
ISSN	22192840
e-ISSN	22192840
Journal	World Journal of Gastroenterology : WJG
Issue Number	40
Volume Number	20
Language	English
Publisher	Baishideng Publishing Group Inc
Publisher Date	2014-10-28
Access Restriction	Open
Rights Holder	Baishideng Publishing Group Inc
Subject Keyword	Research in Higher Education
Content Type	Text
Resource Type	Article

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