NDLI: Animal models and therapeutic molecular targets of cancer: utility and limitations

Content Provider	PubMed Central
Author	Maria, Cekanova Rathore, Kusum
Copyright Year	2014
Abstract	Cancer is the term used to describe over 100 diseases that share several common hallmarks. Despite prevention, early detection, and novel therapies, cancer is still the second leading cause of death in the USA. Successful bench-to-bedside translation of basic scientific findings about cancer into therapeutic interventions for patients depends on the selection of appropriate animal experimental models. Cancer research uses animal and human cancer cell lines in vitro to study biochemical pathways in these cancer cells. In this review, we summarize the important animal models of cancer with focus on their advantages and limitations. Mouse cancer models are well known, and are frequently used for cancer research. Rodent models have revolutionized our ability to study gene and protein functions in vivo and to better understand their molecular pathways and mechanisms. Xenograft and chemically or genetically induced mouse cancers are the most commonly used rodent cancer models. Companion animals with spontaneous neoplasms are still an underexploited tool for making rapid advances in human and veterinary cancer therapies by testing new drugs and delivery systems that have shown promise in vitro and in vivo in mouse models. Companion animals have a relatively high incidence of cancers, with biological behavior, response to therapy, and response to cytotoxic agents similar to those in humans. Shorter overall lifespan and more rapid disease progression are factors contributing to the advantages of a companion animal model. In addition, the current focus is on discovering molecular targets for new therapeutic drugs to improve survival and quality of life in cancer patients.
Related Links	http://dx.doi.org/10.2147/dddt.s49584
Ending Page	1922
Page Count	12
Starting Page	1911
File Format	PDF
ISSN	11778881
e-ISSN	11778881
Journal	Drug Design, Development and Therapy
Volume Number	8
Language	English
Publisher	Dove Medical Press
Publisher Date	2014-10-01
Access Restriction	Open
Rights Holder	Dove Medical Press
Subject Keyword	Pharmacology Drug Discovery Pharmaceutical Science Research in Higher Education
Content Type	Text
Resource Type	Article
Subject	Drug Discovery Pharmacology Pharmaceutical Science

Sl.	Authority	Responsibilities	Communication Details
1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
2	Indian Institute of Technology Kharagpur	Host Institute of the Project: The host institute of the project is responsible for providing infrastructure support and hosting the project	https://www.iitkgp.ac.in
3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
5	Website/Portal (Helpdesk)	Queries regarding NDLI and its services	support@ndl.gov.in
6	Contents and Copyright Issues	Queries related to content curation and copyright issues	content@ndl.gov.in
7	National Digital Library of India Club (NDLI Club)	Queries related to NDLI Club formation, support, user awareness program, seminar/symposium, collaboration, social media, promotion, and outreach	clubsupport@ndl.gov.in
8	Digital Preservation Centre (DPC)	Assistance with digitizing and archiving copyright-free printed books	dpc@ndl.gov.in
9	IDR Setup or Support	Queries related to establishment and support of Institutional Digital Repository (IDR) and IDR workshops	idr@ndl.gov.in

Molecular targets in urothelial cancer: detection, treatment, and animal models of bladder cancer

Advances in the proteomic discovery of novel therapeutic targets in cancer

Cancer research: from prognostic genes to therapeutic targets

Scientometrics of drug discovery efforts: pain-related molecular targets

Advances in the proteomic discovery of novel therapeutic targets in cancer

Epigenetic Control and Cancer: The Potential of Histone Demethylases as Therapeutic Targets

Structures, Targets and Recent Approaches in Anti-Leishmanial Drug Discovery and Development

Animal models of ulcerative colitis and their application in drug research

Distinct prognostic values and potential drug targets of ALDH1 isoenzymes in non-small-cell lung cancer

Animal models and therapeutic molecular targets of cancer: utility and limitations

Similar Documents

Molecular targets in urothelial cancer: detection, treatment, and animal models of bladder cancer

Advances in the proteomic discovery of novel therapeutic targets in cancer

Cancer research: from prognostic genes to therapeutic targets

Scientometrics of drug discovery efforts: pain-related molecular targets

Advances in the proteomic discovery of novel therapeutic targets in cancer

Epigenetic Control and Cancer: The Potential of Histone Demethylases as Therapeutic Targets

Structures, Targets and Recent Approaches in Anti-Leishmanial Drug Discovery and Development

Animal models of ulcerative colitis and their application in drug research

Distinct prognostic values and potential drug targets of ALDH1 isoenzymes in non-small-cell lung cancer

Animal models and therapeutic molecular targets of cancer: utility and limitations