NDLI: Analyses of Entry Mechanisms of Novel Emerging Viruses Using Pseudotype VSV System

Content Provider	PubMed Central
Author	Tani, Hideki
Copyright Year	2014
Abstract	Emerging infectious diseases include newly identified diseases caused by previously unknown organisms or diseases found in new and expanding geographic areas. Viruses capable of causing clinical disease associated with fever and bleeding are referred to as viral hemorrhagic fevers (VHFs). Arenaviruses and Bunyaviruses, both belonging to families classified as VHFs are considered major etiologies of hemorrhagic fevers caused by emerging viruses; having significant clinical and public health impact. Because these viruses are categorized as Biosafety Level (BSL) 3 and 4 pathogens, restricting their use, biological studies including therapeutic drug and vaccine development have been impeded. Due to these restrictions and the difficulties in handling such live viruses, pseudotype viruses bearing envelope proteins of VHF viruses have been developed using vesicular stomatitis virus (VSV) as a surrogate system. Here, we report the successful developments of two pseudotype VSV systems; bearing the envelope proteins of Lujo virus and severe fever with thrombocytopenia syndrome (SFTS) virus, both recently identified viruses of the family Arenaviridae and Bunyaviridae, respectively. My presentation will summarize the characterization of the envelope proteins of Lujo virus including its cellular receptor use and cell entry mechanisms. In addition, I will also present a brief introduction of SFTS reported in Japan and the diagnostic studies in progress using these newly pseudotype VSV system.
Related Links	http://dx.doi.org/10.2149/tmh.2014-S10
Ending Page	82
Page Count	12
Starting Page	71
File Format	PDF
ISSN	13494147
e-ISSN	13494147
Journal	Tropical Medicine and Health
Issue Number	2 Suppl
Volume Number	42
Language	English
Publisher	The Japanese Society of Tropical Medicine
Publisher Date	2014-06-01
Access Restriction	Open
Rights Holder	The Japanese Society of Tropical Medicine
Subject Keyword	Research in Higher Education
Content Type	Text
Resource Type	Article
Subject	Infectious Diseases Public Health, Environmental and Occupational Health

Sl.	Authority	Responsibilities	Communication Details
1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
2	Indian Institute of Technology Kharagpur	Host Institute of the Project: The host institute of the project is responsible for providing infrastructure support and hosting the project	https://www.iitkgp.ac.in
3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
5	Website/Portal (Helpdesk)	Queries regarding NDLI and its services	support@ndl.gov.in
6	Contents and Copyright Issues	Queries related to content curation and copyright issues	content@ndl.gov.in
7	National Digital Library of India Club (NDLI Club)	Queries related to NDLI Club formation, support, user awareness program, seminar/symposium, collaboration, social media, promotion, and outreach	clubsupport@ndl.gov.in
8	Digital Preservation Centre (DPC)	Assistance with digitizing and archiving copyright-free printed books	dpc@ndl.gov.in
9	IDR Setup or Support	Queries related to establishment and support of Institutional Digital Repository (IDR) and IDR workshops	idr@ndl.gov.in

Requirements of New Vaccines against Novel Influenza Viruses

Viral RNA Intermediates as Targets for Detection and Discovery of Novel and Emerging Mosquito-Borne Viruses

Bats: Important Reservoir Hosts of Emerging Viruses

Development of novel entry inhibitors targeting emerging viruses

Where are macrophage-tropic viruses?

Fear of Foreigners: HIV-related restrictions on entry, stay, and residence

Inhibition of Dengue Virus Entry and Multiplication into Monocytes Using RNA Interference

Emerging and Re-emerging Infectious Diseases: Public Health Perspective

Engineering Temperature Sensitive Live Attenuated Influenza Vaccines from Emerging Viruses

Analyses of Entry Mechanisms of Novel Emerging Viruses Using Pseudotype VSV System

Similar Documents

Requirements of New Vaccines against Novel Influenza Viruses

Viral RNA Intermediates as Targets for Detection and Discovery of Novel and Emerging Mosquito-Borne Viruses

Bats: Important Reservoir Hosts of Emerging Viruses

Development of novel entry inhibitors targeting emerging viruses

Where are macrophage-tropic viruses?

Fear of Foreigners: HIV-related restrictions on entry, stay, and residence

Inhibition of Dengue Virus Entry and Multiplication into Monocytes Using RNA Interference

Emerging and Re-emerging Infectious Diseases: Public Health Perspective

Engineering Temperature Sensitive Live Attenuated Influenza Vaccines from Emerging Viruses

Analyses of Entry Mechanisms of Novel Emerging Viruses Using Pseudotype VSV System