NDLI: Enlarged meristems and delayed growth in plp mutants result from lack of CaaX prenyltransferases

Content Provider	PubMed Central
Author	Running, Mark P. Lavy, Meirav Sternberg, Hasana Arnaud, Galichet Wilhelm, Gruissem Hake, Sarah Ori, Naomi Shaul, Yalovsky
Copyright Year	2004
Abstract	Meristems require a myriad of intercellular signaling pathways for coordination of cell division within and between functional zones and clonal cell layers. This control of cell division ensures a constant availability of stem cells throughout the life span of the meristem while limiting overproliferation of meristematic cells and maintaining the meristem structure. We have undertaken a genetic screen to identify additional components of meristem signaling pathways. We identified pluripetala (plp) mutants based on their dramatically larger meristems and increased floral organ number. PLURIPETALA encodes the α-subunit shared between protein farnesyltransferase and protein geranylgeranyltransferase-I. plp mutants also have altered abscisic acid responses and overall much slower growth rate. plp is epistatic to mutations in the β-subunit of farnesyltransferase and shows a synergistic interaction with clavata3 mutants. plp mutants lead to insights into the mechanism of meristem homeostasis and provide a unique in vivo system for studying the functional role of prenylation in eukaryotes.
Related Links	http://dx.doi.org/10.1073/pnas.0402385101
Ending Page	7820
Page Count	6
Starting Page	7815
File Format	PDF
ISSN	00278424
e-ISSN	10916490
Journal	Proceedings of the National Academy of Sciences of the United States of America
Issue Number	20
Volume Number	101
Language	English
Publisher	National Academy of Sciences
Publisher Date	2004-05-18
Access Restriction	Open
Rights Holder	National Academy of Sciences
Subject Keyword	General Research in Higher Education
Content Type	Text
Resource Type	Article
Subject	Multidisciplinary

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