NDLI: Targeted transcriptional repression of Gfi1 by GFI1 and GFI1B in lymphoid cells

Content Provider	PubMed Central
Author	Doan, Loretta L. Porter, Susan D. Duan, Zhijun Flubacher, Marcella M. Montoya, Diego Tsichlis, Philip N. Horwitz, Marshall Gilks, C. Blake Grimes, H. Leighton
Copyright Year	2004
Abstract	Growth factor independence-1 (GFI1) and GFI1B are closely related, yet differentially expressed transcriptional repressors with nearly identical DNA binding domains. GFI1 is upregulated in the earliest thymocyte precursors, while GFI1B expression is restricted to T lymphopoiesis stages coincident with activation. Transgenic expression of GFI1 potentiates T-cell activation, while forced GFI1B expression decreases activation. Both mice and humans with mutant Gfi1 display lymphoid abnormalities. Here we describe autoregulation of Gfi1 in primary mouse thymocytes and a human T-cell line. GFI1 binding to cis-element sequences conserved between rat, mouse and human Gfi1 mediates direct and potent transcriptional repression. In addition, dramatic regulation of Gfi1 can also be mediated by GFI1B. These data provide the first example of a gene directly targeted by GFI1 and GFI1B. Moreover, they support a role for auto- and trans-regulation of Gfi1 by GFI1 and GFI1B in maintaining the normal expression patterns of Gfi1, and suggest that GFI1B may indirectly affect T-cell activation through repression of Gfi1.
Related Links	http://dx.doi.org/10.1093/nar/gkh570
Ending Page	2519
Page Count	12
Starting Page	2508
File Format	PDF
ISSN	13624962
e-ISSN	13624962
Journal	Nucleic Acids Research
Issue Number	8
Volume Number	32
Language	English
Publisher	Oxford University Press
Publisher Date	2004-04-28
Access Restriction	Open
Rights Holder	Oxford University Press
Subject Keyword	Genetics Research in Higher Education
Content Type	Text
Resource Type	Article
Subject	Genetics

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