NDLI: Metabolic dysfunction drives a mechanistically distinct pro-inflammatory phenotype in adipose tissue macrophages

Content Provider	PubMed Central
Author	Kratz, Mario Coats, Brittney R. Hisert, Katherine B. Hagman, Derek Vesco, Mutskov Peris, Eduard Schoenfelt, Kelly Q. Kuzma, Jessica N. Larson, Ilona Billing, Peter S. Landerholm, Robert W. Crouthamel, Matthew David, Gozal Hwang, Seungmin Singh, Pradeep Becker, Lev
Copyright Year	2014
Abstract	Adipose tissue macrophage (ATM)-driven inflammation plays a key role in insulin resistance; however, factors activating ATMs are poorly understood. Using a proteomics approach, we show that markers of classical activation are absent on ATMs from obese humans, but readily detectable on airway macrophages of patients with cystic fibrosis, a disease of chronic bacterial infection. Moreover, treating macrophages with glucose, insulin, and palmitate – conditions characteristic of the metabolic syndrome – produces a ‘metabolically-activated’ phenotype distinct from classical activation. Markers of metabolic activation are expressed by pro-inflammatory ATMs in obese humans/mice and are positively correlated with adiposity. Metabolic activation is driven by independent pro- and anti-inflammatory pathways, which regulate balance between cytokine production and lipid metabolism. We identify PPARγ and p62/SQSTM1 as two key proteins that promote lipid metabolism and limit inflammation in metabolically-activated macrophages. Collectively, our data provide important mechanistic insights into pathways that drive the metabolic disease-specific phenotype of macrophages.
Related Links	http://dx.doi.org/10.1016/j.cmet.2014.08.010
Ending Page	625
Page Count	12
Starting Page	614
File Format	PDF
ISSN	19327420
e-ISSN	19327420
Journal	Cell metabolism
Issue Number	4
Volume Number	20
Language	English
Publisher Date	2014-10-07
Access Restriction	Open
Subject Keyword	Research in Higher Education
Content Type	Text
Resource Type	Article
Subject	Cell Biology Physiology Molecular Biology

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