NDLI: Common genetic variants associated with cognitive performance identified using the proxy-phenotype method

Content Provider	PubMed Central
Author	Rietveld, Cornelius A. Esko, Tõnu Davies, Gail Pers, Tune H. Turley, Patrick Benyamin, Beben Chabris, Christopher F. Emilsson, Valur Johnson, Andrew D. Lee, James J. Leeuw, Christiaan De Marioni, Riccardo E. Medland, Sarah E. Miller, Michael B. Olga, Rostapshova Lee, Sven J. Van Der Vinkhuyzen, Anna A. E. Amin, Najaf Conley, Dalton Derringer, Jaime Duijn, Cornelia M. Van Fehrmann, Rudolf Franke, Lude Glaeser, Edward L. Hansell, Narelle K. Hayward, Caroline Iacono, William G. Ibrahim-verbaas, Carla Vincent, Jaddoe Karjalainen, Juha Laibson, David Lichtenstein, Paul Liewald, David C. Magnusson, Patrik K. E. Martin, Nicholas G. Mcgue, Matt Mcmahon, George Pedersen, Nancy L. Pinker, Steven Porteous, David J. Posthuma, Danielle Rivadeneira, Fernando Smith, Blair H. Starr, John M. Henning, Tiemeier Timpson, Nicholas J. Trzaskowski, Maciej Uitterlinden, André G. Verhulst, Frank C. Ward, Mary E. Wright, Margaret J. Smith, George Davey Deary, Ian J. Johannesson, Magnus Plomin, Robert Visscher, Peter M. Benjamin, Daniel J. Cesarini, David Koellinger, Philipp D.
Abstract	We identify several common genetic variants associated with cognitive performance using a two-stage approach: we conduct a genome-wide association study of educational attainment to generate a set of candidates, and then we estimate the association of these variants with cognitive performance. In older Americans, we find that these variants are jointly associated with cognitive health. Bioinformatics analyses implicate a set of genes that is associated with a particular neurotransmitter pathway involved in synaptic plasticity, the main cellular mechanism for learning and memory. In addition to the substantive contribution, this work also serves to show a proxy-phenotype approach to discovering common genetic variants that is likely to be useful for many phenotypes of interest to social scientists (such as personality traits).
Related Links	http://dx.doi.org/10.1073/pnas.1404623111
Ending Page	13794
Page Count	5
Starting Page	13790
File Format	PDF
ISSN	10916490
e-ISSN	10916490
Journal	Proceedings of the National Academy of Sciences of the United States of America
Issue Number	38
Volume Number	111
Language	English
Publisher	National Academy of Sciences
Publisher Date	2014-09-23
Access Restriction	Open
Rights Holder	National Academy of Sciences
Subject Keyword	Research in Higher Education
Content Type	Text
Resource Type	Article
Subject	Multidisciplinary

Sl.	Authority	Responsibilities	Communication Details
1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
2	Indian Institute of Technology Kharagpur	Host Institute of the Project: The host institute of the project is responsible for providing infrastructure support and hosting the project	https://www.iitkgp.ac.in
3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
5	Website/Portal (Helpdesk)	Queries regarding NDLI and its services	support@ndl.gov.in
6	Contents and Copyright Issues	Queries related to content curation and copyright issues	content@ndl.gov.in
7	National Digital Library of India Club (NDLI Club)	Queries related to NDLI Club formation, support, user awareness program, seminar/symposium, collaboration, social media, promotion, and outreach	clubsupport@ndl.gov.in
8	Digital Preservation Centre (DPC)	Assistance with digitizing and archiving copyright-free printed books	dpc@ndl.gov.in
9	IDR Setup or Support	Queries related to establishment and support of Institutional Digital Repository (IDR) and IDR workshops	idr@ndl.gov.in

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