NDLI: High Eomesodermin Expression among CD57+ CD8+ T Cells Identifies a CD8+ T Cell Subset Associated with Viral Control during Chronic Human Immunodeficiency Virus Infection

Content Provider	PubMed Central
Author	Simonetta, Federico Hua, Stéphane Camille, Lécuroux Gérard, Sandie Boufassa, Faroudy Sáez-cirión, Asier Pancino, Gianfranco Goujard, Cécile Olivier, Lambotte Venet, Alain Bourgeois, Christine
Editor	Silvestri, G.
Copyright Year	2014
Abstract	During HIV infection, increased CD57 expression among CD8+ T cells has been associated with immune senescence and defective immune responses. Interestingly, CD57-expressing CD8+ T cells exhibit a dual profile, being simultaneously highly cytotoxic (terminally differentiated effectors) and poorly proliferative (replicative senescent). Recent publications point toward a positive role of CD57-expressing CD8+ T cell subsets, presumably due to their high cytolytic activity. We further investigated the phenotype of CD57-expressing CD8+ T cells in healthy donors and during HIV infection combining CD57 expression to Eomesodermin (EOMES), a T box transcription factor which determines, coordinately with T-bet, effector and memory CD8+ T cell differentiation. We defined in healthy donors two functionally distinct CD57-expressing CD8+ T cell subsets exhibiting different levels of EOMES expression: EOMEShi CD57+ and EOMESint CD57+ CD8+ T cells. EOMEShi CD57+ cells exhibited low cytotoxic activity but preserved proliferative capacity and interleukin 7 (IL-7) receptor expression, whereas EOMESint CD57+ cells exhibited obvious cytotoxic functions and a more terminally differentiated phenotype. We next performed a similar analysis in different contexts of HIV infection: primary infected patients, long-term viremic patients, aviremic patients treated with antiretroviral therapy, and HIV controllers; we demonstrated a higher percentage of CD57-expressing cells in all HIV-infected patients regardless of virological status. When heterogeneity in EOMES expression among CD57 cells was taken into account, we detected significantly higher proportions of EOMEShi CD57+ cells among HIV-specific and nonspecific CD8+ T cells from HIV controllers than in aviremic antiretroviral-treated patients and viremic patients. Importantly, such a peculiar non-terminally differentiated EOMEShi CD57+ phenotypic profile was associated with viral control.
Related Links	http://dx.doi.org/10.1128/JVI.02013-14
Ending Page	11871
Page Count	11
Starting Page	11861
File Format	PDF
ISSN	10985514
e-ISSN	10985514
Journal	Journal of Virology
Issue Number	20
Volume Number	88
Language	English
Publisher	American Society for Microbiology
Publisher Date	2014-10-01
Access Restriction	Open
Rights Holder	American Society for Microbiology
Subject Keyword	Research in Higher Education
Content Type	Text
Resource Type	Article
Subject	Virology Immunology Microbiology Insect Science

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