NDLI: Synthetic Triterpenoid Cyano Enone of Methyl Boswellate (CEMB) activates intrinsic, extrinsic, & endoplasmic reticulum stress cell death pathways in tumor cell lines

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Synthetic Triterpenoid Cyano Enone of Methyl Boswellate (CEMB) activates intrinsic, extrinsic, & endoplasmic reticulum stress cell death pathways in tumor cell lines

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Synthetic Triterpenoid Cyano Enone of Methyl Boswellate (CEMB) activates intrinsic, extrinsic, & endoplasmic reticulum stress cell death pathways in tumor cell lines

Content Provider	PubMed Central
Author	Ravanan, Palaniyandi Sano, Renata Priti, Talwar Osawagia, Satoshi Matsuzawa, Shuichi Cuddy, Michael Singh, Sanjay K. Rao, G. S. R. Subba Kondaiah, Paturu Reed, John C.
Abstract	We explored the effect of a novel synthetic triterpenoid compound Cyano Enone of Methyl Boswellates (CEMB) on various prostate cancer and glioma cancer cell lines. CEMB displayed concentration-dependent cytotoxic activity with submicromolar lethal dose 50% (LD50) values in ten of ten tumor cell lines tested. CEMB-induced cytotoxicity is accompanied by activation of downstream effector caspases (caspases 3 and 7) and by upstream initiator caspases involved in both the extrinsic (caspase 8) and intrinsic (caspase 9) apoptotic pathways. By using small interfering RNAs (siRNAs), we show evidence that knock down of caspase 8, death receptor 4 (DR4), Apaf-1, and Bid impairs CEMB-induced cell death. Similar to other proapoptotic synthetic triterpenoid compounds, CEMB-induced apoptosis involved endoplasmic reticulum (ER) stress, as demonstrated by partial rescue of tumor cells by siRNA-mediated knock-down of expression of genes involve in the unfolded protein response such as Ire1, Perk, and ATF6. Altogether our results suggest that CEMB stimulates several apoptotic pathways in cancer cells, suggesting that this compound should be evaluated further as a potential agent for cancer therapy.
Related Links	http://dx.doi.org/10.1158/1535-7163.mct-10-0887
Ending Page	1643
Page Count	9
Starting Page	1635
File Format	PDF
ISSN	15357163
e-ISSN	15388514
Journal	Molecular cancer therapeutics
Issue Number	9
Volume Number	10
Language	English
Publisher Date	2011-09-01
Access Restriction	Open
Subject Keyword	Cancer Research Oncology Research in Higher Education
Content Type	Text
Resource Type	Article
Subject	Cancer Research Oncology

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