NDLI: Regulation of rhythm genesis by volume-limited, astroglia-like signals in neural networks

Content Provider	PubMed Central
Author	Savtchenko, Leonid P. Rusakov, Dmitri A.
Copyright Year	2014
Abstract	Rhythmic activity of the brain often depends on synchronized spiking of interneuronal networks interacting with principal neurons. The quest for physiological mechanisms regulating network synchronization has therefore been firmly focused on synaptic circuits. However, it has recently emerged that synaptic efficacy could be influenced by astrocytes that release signalling molecules into their macroscopic vicinity. To understand how this volume-limited synaptic regulation can affect oscillations in neural populations, here we explore an established artificial neural network mimicking hippocampal basket cells receiving inputs from pyramidal cells. We find that network oscillation frequencies and average cell firing rates are resilient to changes in excitatory input even when such changes occur in a significant proportion of participating interneurons, be they randomly distributed or clustered in space. The astroglia-like, volume-limited regulation of excitatory synaptic input appears to better preserve network synchronization (compared with a similar action evenly spread across the network) while leading to a structural segmentation of the network into cell subgroups with distinct firing patterns. These observations provide us with some previously unknown insights into the basic principles of neural network control by astroglia.
Related Links	http://dx.doi.org/10.1098/rstb.2013.0614
Starting Page	20130614
File Format	PDF
ISSN	14712970
e-ISSN	14712970
Journal	Philosophical Transactions of the Royal Society B: Biological Sciences
Issue Number	1654
Volume Number	369
Language	English
Publisher	The Royal Society
Publisher Date	2014-10-19
Access Restriction	Open
Rights Holder	The Royal Society
Subject Keyword	Research in Higher Education
Content Type	Text
Resource Type	Article
Subject	Biochemistry, Genetics and Molecular Biology Agricultural and Biological Sciences

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1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
2	Indian Institute of Technology Kharagpur	Host Institute of the Project: The host institute of the project is responsible for providing infrastructure support and hosting the project	https://www.iitkgp.ac.in
3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
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