NDLI: Regulatory role of miR-142-3p on the functional hepatic cancer stem cell marker CD133

Content Provider	PubMed Central
Author	Chai, Stella Tong, Man Ng, Kai Yu Kwan, Pak Shing Chan, Yuen Piu Fung, Tsun Ming Lee, Terence K. Wong, Nathalie Xie, Dan Yuan, Yun-fei Guan, Xin-yuan Stephanie, Ma
Copyright Year	2014
Abstract	Tumor relapse after therapy typifies hepatocellular carcinoma (HCC) and is believed to be attributable to residual cancer stem cells (CSCs) that survive treatment. We have previously identified a CSC population derived from HCC that is characterized by CD133. Despite our growing knowledge of the importance of this subset of cells in driving HCC, the regulatory mechanism of CD133 is not known. Epigenetic changes are believed to be essential in the control of cancer and stem cells. Here, we report the epigenetic regulation of CD133 by miR-142-3p. The interaction between CD133 and miR-142-3p was identified by in silico prediction and substantiated by luciferase reporter analysis. Expression of CD133 was found to be inversely correlated with miR-142-3p in HCC clinical samples as well as in cell lines. Importantly, lower miR-142-3p expression in HCC was significantly associated with worst survival. Functional studies with miR-142-3p stably transduced in HCC cells demonstrated a diminished ability to self-renew, initiate tumor growth, invade, migrate, induce angiogenesis and resist chemotherapy. Rescue experiments whereby CD133 and miR-142-3p is simultaneously overexpressed compensated the deregulated ability of the cells to confer these features. Thus, miR-142-3p directly targets CD133 to regulate its ability to confer cancer and stem cell-like features in HCC.
Related Links	http://dx.doi.org/10.18632/oncotarget.2167
Ending Page	5735
Page Count	11
Starting Page	5725
File Format	PDF
ISSN	19492553
e-ISSN	19492553
Journal	Oncotarget
Issue Number	14
Volume Number	5
Language	English
Publisher	Impact Journals LLC
Publisher Date	2014-08-01
Access Restriction	Open
Rights Holder	Impact Journals LLC
Subject Keyword	Medicine(all) Research in Higher Education
Content Type	Text
Resource Type	Article
Subject	Oncology

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