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| Content Provider | PubMed Central |
|---|---|
| Author | Hill, Alison L. Rosenbloom, Daniel I. S. Feng, Fu Nowak, Martin A. Siliciano, Robert F. |
| Abstract | HIV infection cannot be cured by current antiretroviral drugs, due to the presence of long-lived latently infected cells. New antilatency drugs are being tested in clinical trials, but major unknowns remain. It is unclear how much latent virus must be eliminated for a cure, which remains difficult to answer empirically due to few case studies and limited sensitivity of viral reservoir assays. In this paper, we introduce a mathematical model of HIV dynamics to calculate the likelihood and timing of viral rebound following antilatency treatment. We derive predictions for the required efficacy of antilatency drugs, and demonstrate that rebound times may be highly variable and occur after years of remission. These results will aid in designing and interpreting HIV cure studies. |
| Related Links | http://dx.doi.org/10.1073/pnas.1406663111 |
| Ending Page | 13480 |
| Page Count | 6 |
| Starting Page | 13475 |
| File Format | |
| ISSN | 10916490 |
| e-ISSN | 10916490 |
| Journal | Proceedings of the National Academy of Sciences of the United States of America |
| Issue Number | 37 |
| Volume Number | 111 |
| Language | English |
| Publisher | National Academy of Sciences |
| Publisher Date | 2014-09-16 |
| Access Restriction | Open |
| Rights Holder | National Academy of Sciences |
| Subject Keyword | Research in Higher Education |
| Content Type | Text |
| Resource Type | Article |
| Subject | Multidisciplinary |
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