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| Content Provider | PubMed Central |
|---|---|
| Author | Gregg, Christopher |
| Copyright Year | 2014 |
| Abstract | Recent studies have provided evidence for non-canonical imprinting effects that are associated with allele-specific expression biases at the tissue level in mice. These imprinting effects have features that are distinct from canonical imprinting effects that involve allele silencing. Here, I discuss some of the evidence for non-canonical imprinting effects in the context of random X-inactivation and epigenetic allele-specific expression effects on the autosomes. I propose several mechanisms that may underlie non-canonical imprinting effects and outline future directions and approaches to study these effects at the cellular level in vivo. The growing evidence for complex allele-specific expression effects that are cell- and developmental stage-specific has opened a new frontier for study. Currently, the function of these effects and the underlying regulatory mechanisms are largely unknown. |
| Related Links | http://dx.doi.org/10.12703/p6-75 |
| Starting Page | 75 |
| File Format | |
| ISSN | 20517599 |
| e-ISSN | 20517599 |
| Journal | F1000Prime Reports |
| Volume Number | 6 |
| Language | English |
| Publisher | Faculty of 1000 Ltd |
| Publisher Date | 2014-09-01 |
| Access Restriction | Open |
| Rights Holder | Faculty of 1000 Ltd |
| Subject Keyword | Research in Higher Education |
| Content Type | Text |
| Resource Type | Article |
| Subject | Medicine |
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