NDLI: New insights on contraction efficiency in patients with Duchenne muscular dystrophy

Content Provider	PubMed Central
Author	Lacourpaille, Lilian Hug, François Arnaud, Guével Yann, Péréon Magot, Armelle Hogrel, Jean-yves Antoine, Nordez
Copyright Year	2014
Abstract	The decrease in muscle strength in patients with Duchenne muscular dystrophy (DMD) is mainly explained by a decrease in the number of active contractile elements. Nevertheless, it is possible that other electrochemical and force transmission processes may contribute. The present study aimed to quantify the effect of DMD on the relative contribution of electrochemical and force transmission components of the electromechanical delay (i.e., time lag between the onset of muscle activation and force production) in humans using very high frame rate ultrasound. Fourteen patients with DMD and thirteen control subjects underwent two electrically evoked contractions of the biceps brachii with the ultrasound probe over the muscle belly. The electromechanical delay was significantly longer in DMD patients compared with controls (18.5 ± 3.9 vs. 12.5 ± 1.4 ms, P < 0.0001). More precisely, DMD patients exhibited a longer delay between the onset of muscle fascicles motion and force production (13.6 ± 3.1 vs. 7.9 ± 2.0 ms, P < 0.0001). This delay was correlated to the chronological age of the DMD patients (r = 0.66; P = 0.01), but not of the controls (r = −0.45; P = 0.10). No significant difference was found for the delay between the onset of muscle stimulation and the onset of muscle fascicle motion. These results highlight the role of the alteration of muscle force transmission (delay between the onset of fascicle motion and force production) in the impairments of the contraction efficiency in patients with DMD.
Related Links	http://dx.doi.org/10.1152/japplphysiol.00544.2014
Ending Page	662
Page Count	5
Starting Page	658
File Format	PDF
ISSN	87507587
e-ISSN	15221601
Journal	Journal of Applied Physiology
Issue Number	6
Volume Number	117
Language	English
Publisher	American Physiological Society
Publisher Date	2014-09-15
Access Restriction	Open
Rights Holder	American Physiological Society
Subject Keyword	Physiology (medical) Physiology Research in Higher Education
Content Type	Text
Resource Type	Article
Subject	Physiology Physiology (medical) Sports Science

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