NDLI: Infection with Toxoplasma gondii Increases Atherosclerotic Lesion in ApoE-Deficient Mice

Content Provider	PubMed Central
Author	Portugal, Luciane R. Fernandes, Luciana R. Cesar, Giovana C. Santiago, Helton C. Oliveira, Dirce R. Silva, Neide M. Silva, Andrea A. Lannes-vieira, Joseli Arantes, Rosa M. E. Gazzinelli, Ricardo T. Alvarez-leite, Jacqueline I.
Copyright Year	2004
Abstract	Toxoplasma gondii is an intracellular protozoan that elicits a potent inflammatory response during the acute phase of infection. Herein, we evaluate whether T. gondii infection alters the natural course of aortic lesions. ApoE knockout mice were infected with T. gondii, and at 5 weeks of infection, serum, feces, and liver cholesterol; aortic lesion size, cellularity, and inflammatory cytokines; and levels of serum nitrite and gamma interferon (IFN-γ) were analyzed. Our results showed that serum cholesterol and atherogenic lipoproteins were reduced after T. gondii infection. The reduction of serum levels of total cholesterol and atherogenic lipoproteins was associated with increases in the aortic lesion area, numbers of inflammatory cells, and expression of monocyte chemoattractant protein 1 and inducible nitric oxide synthase mRNA in the site of lesions as well as elevated concentrations of IFN-γ and nitrite in sera of T. gondii-infected animals. These results suggest that infection with T. gondii accelerates atherosclerotic development by stimulating the proinflammatory response and oxidative stress, thereby increasing the area of aortic lesion.
Related Links	http://dx.doi.org/10.1128/iai.72.6.3571-3576.2004
Ending Page	3576
Page Count	6
Starting Page	3571
File Format	PDF
ISSN	00199567
e-ISSN	10985522
Journal	Infection and Immunity
Issue Number	6
Volume Number	72
Language	English
Publisher	American Society for Microbiology
Publisher Date	2004-06-01
Access Restriction	Open
Rights Holder	American Society for Microbiology
Subject Keyword	Immunology Microbiology Parasitology Infectious Diseases Research in Higher Education
Content Type	Text
Resource Type	Article
Subject	Infectious Diseases Parasitology Immunology Microbiology

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