NDLI: Layered double hydroxide nanocomposite for drug delivery systems; bio-distribution, toxicity and drug activity enhancement

Please wait, while we are loading the content...

Year: 2016, Volume: 10

Year: 2015, Volume: 9

Year: 2014, Volume: 8

Year: 2014, Volume: 8, Issue: Unspecified

Quantum chemical assessment of benzimidazole derivatives as corrosion inhibitors

Assessing antibiotic sorption in soil: a literature review and new case studies on sulfonamides and macrolides

Use of coupled ion mobility spectrometry-time of flight mass spectrometry to analyze saturated and unsaturated phenylpropanoic acids and chalcones

Syntheses and characterization of two novel tetranuclear lead(II) clusters self-assembled by hydrogen bonded interactions

One-pot method of synthesis of Pt/SnO2 system and its electrocatalytic activity

Environmentally evaluated HPLC-ELSD method to monitor enzymatic synthesis of a non-ionic surfactant

Potentiometric determination of moxifloxacin in some pharmaceutical formulation using PVC membrane sensors

Structural transformation induced by locked nucleic acid or 2′–O-methyl nucleic acid site-specific modifications on thrombin binding aptamer

Stirring time effect of silver nanoparticles prepared in glutathione mediated by green method

Design of co-crystals/salts of some Nitrogenous bases and some derivatives of thiophene carboxylic acids through a combination of hydrogen and halogen bonds

Charge density analysis for crystal engineering

General peroxidase activity of a parallel G-quadruplex-hemin DNAzyme formed by Pu39WT - a mixed G-quadruplex forming sequence in the Bcl-2 P1 promoter

Regioselective synthesis of 2-(bromomethyl)-5-aryl-thiophene derivatives via palladium (0) catalyzed suzuki cross-coupling reactions: as antithrombotic and haemolytically active molecules

Study on essential oils from four species of Zhishi with gas chromatography–mass spectrometry

Biological effects of a new set 1,2,4-triazolo[1,5-a]quinazolines on heart rate and blood pressure

Modified method to improve the design of Petlyuk distillation columns

Boronic acids for sensing and other applications - a mini-review of papers published in 2013

Growth and dislocation studies of β-HMX

A review of phytochemistry, metabolite changes, and medicinal uses of the common food mung bean and its sprouts (Vigna radiata)

Uptake and sorption of aluminium and fluoride by four green algal species

Evaluation of solvent effect on the extraction of phenolic compounds and antioxidant capacities from the berries: application of principal component analysis

A review of what is an emerging contaminant

Comparison of binder compositions in Pompeian wall painting styles from Insula Occidentalis

Upgrading oxygenated Fischer-Tropsch derivatives and one-step direct synthesis of ethyl acetate from ethanol - examples of the desirability of research on simple chemical compounds transformations

Chemical composition and in vitro evaluation of the cytotoxic and antioxidant activities of supercritical carbon dioxide extracts of pitaya (dragon fruit) peel

Synthesis, reactivity and application studies for different biolubricants

Chemical characterization by GC-MS and in vitro activity against Candida albicans of volatile fractions prepared from Artemisia dracunculus, Artemisia abrotanum, Artemisia absinthium and Artemisia vulgaris

PM10 and gaseous pollutants trends from air quality monitoring networks in Bari province: principal component analysis and absolute principal component scores on a two years and half data set

Composition of essential oils of four Hedychium species from Vietnam

Synthesis, characterization, electrospinning and antibacterial studies on triphenylphosphine-dithiphosphonates Copper(I) and Silver(I) complexes

Coordinative interaction of microcrystalline chitosan with oxovanadium (IV) ions in aqueous solution

Development and validation of LC/MS/MS method for the simultaneous determination of montelukast, gliclazide, and nifedipine and its application to a pharmacokinetic study

Correction: Determining the degradation efficiency and mechanisms of ethyl violet using HPLC-PDA-ESI-MS and GC-MS

Investigation of supramolecular synthons and structural characterisation of aminopyridine-carboxylic acid derivatives

Heterogeneous base catalysts for edible palm and non-edible Jatropha-based biodiesel production

Polyphenols profile and antioxidant activity of skin and pulp of a rare apple from Marche region (Italy)

Nanotechnology in drug delivery: the need for more cell culture based studies in screening

Analyses of chlorogenic acids and related cinnamic acid derivatives from Nicotiana tabacum tissues with the aid of UPLC-QTOF-MS/MS based on the in-source collision-induced dissociation method

Effect of roasting conditions on color development and Fourier transform infrared spectroscopy (FTIR-ATR) analysis of Malaysian-grown tropical almond nuts (Terminalia catappa L.)

Erratum: General peroxidase activity of a parallel G-quadruplex-hemin DNAzyme formed by Pu39WT - a mixed G-quadruplex forming sequence in the Bcl-2 P1 promoter

Microwave irradiation: synthesis and characterization of α-ketoamide and bis (α-ketoamide) derivatives via the ring opening of N-acetylisatin

New approach to the differentiation of marble samples using thermal analysis and chemometrics in order to identify provenance

Preparation of γ-Fe2O3/ZnFe2O4 nanoparticles by enhancement of surface modification with NaOH

LC–MS/MS determination and pharmacokinetic study of columbianadin in rat plasma after intravenous administration of pure columbianadin

QSPR study on the octanol/air partition coefficient of polybrominated diphenyl ethers by using molecular distance-edge vector index

Validated method to measure yakuchinone A in plasma by LC-MS/MS and its application to a pharmacokinetic study in rats

Anthraquinonyl glycoside facilitates the standardization of graphene electrodes for the impedance detection of lectins

Chemical composition and Biological studies of Ficus benjamina

Development of tartaric esters as bifunctional additives of methanol-gasoline

Simple, sensitive and rapid determination of linifanib (ABT-869), a novel tyrosine kinase inhibitor in rat plasma by UHPLC-MS/MS

Selective phenol methylation to 2,6-dimethylphenol in a fluidized bed of iron-chromium mixed oxide catalyst with o–cresol circulation

Archaeometric classification of ancient human fossil bones, with particular attention to their carbonate content, using chemometrics, thermogravimetry and ICP emission

Catalytic transformation of ethanol into 1,3-butadiene

Importance of halide involving interactions at Hoogsteen sites in supramolecular architectures of some coordination metal complexes of N6-benzyl/furfuryl adenine

Nanomechanics of phospholipid LB film studied layer by layer with AFM

A mechanophysical phase transition provides a dramatic example of colour polymorphism: the tribochromism of a substituted tri(methylene)tetrahydrofuran-2-one

Cytotoxic Benzophenanthridine and Furoquinoline Alkaloids from Zanthoxylum buesgenii (Rutaceae)

Simultaneous determination of tylosin and josamycin residues in muscles, liver, eggs and milk by MLC with a monolithic column and time-programmed UV detection: application to baby food and formulae

Chemistry Central Journal themed issue: Current Topics in Chemical Crystallography

The effect of prime emulsion components as a function of equilibrium headspace concentration of soursop flavor compounds

Characterization of the Vitrocell® 24/48 in vitro aerosol exposure system using mainstream cigarette smoke

Layered double hydroxide nanocomposite for drug delivery systems; bio-distribution, toxicity and drug activity enhancement

Rheoreversible hydrogels in paper restoration processes: a versatile tool

Year: 2013, Volume: 7

Year: 2012, Volume: 6

Year: 2011, Volume: 5

Year: 2010, Volume: 4

Year: 2009, Volume: 3

Year: 2008, Volume: 2

Year: 2007, Volume: 1

Layered double hydroxide nanocomposite for drug delivery systems; bio-distribution, toxicity and drug activity enhancement

Content Provider	PubMed Central
Author	Kura, Aminu Umar Hussein, Md. Zobir Sharida, Fakurazi Arulselvan, Palanisamy
Abstract	The production of layered double hydroxide(LDH) nanocomposite as an alternative drug delivery system against various ailments is on the increase. Their toxicity potential is usually dose and time dependent with particle sizes, shapes and surface charge playing some role both in the in vitro and in vivo studies. The reticular endothelial system of especially the liver and spleen were shown to sequestrate most of these nanocomposite, especially those with sizes greater than 50 nm. The intracellular drug delivery by these particles is mainly via endocytotic pathways aided by the surface charges in most cases. However, structural modification of these nanocomposite via coating using different types of material may lower the toxicity where present. More importantly, the coating may serve as targeting ligand hence, directing drug distribution and leading to proper drug delivery to specific area of need; it equally decreases the unwanted nanocomposite accumulation in especially the liver and spleen. These nanocomposite have the advantage of wider bio-distribution irrespective of route of administration, excellent targeted delivery potential with ease of synthetic modification including coating.
Related Links	http://dx.doi.org/10.1186/s13065-014-0047-2
Starting Page	47
File Format	PDF
ISSN	1752153X
e-ISSN	1752153X
Journal	Chemistry Central Journal
Volume Number	8
Language	English
Publisher	Springer International Publishing
Publisher Date	2014-12-01
Access Restriction	Open
Rights Holder	Springer International Publishing
Subject Keyword	Chemistry(all) Research in Higher Education
Content Type	Text
Resource Type	Article
Subject	Chemistry

Central Library (ISO-9001:2015 Certified)
Indian Institute of Technology Kharagpur
Kharagpur, West Bengal, India | PIN - 721302

See location in the Map
03222 282435
Mail: support@ndl.gov.in

Sl.	Authority	Responsibilities	Communication Details
1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
2	Indian Institute of Technology Kharagpur	Host Institute of the Project: The host institute of the project is responsible for providing infrastructure support and hosting the project	https://www.iitkgp.ac.in
3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
5	Website/Portal (Helpdesk)	Queries regarding NDLI and its services	support@ndl.gov.in
6	Contents and Copyright Issues	Queries related to content curation and copyright issues	content@ndl.gov.in
7	National Digital Library of India Club (NDLI Club)	Queries related to NDLI Club formation, support, user awareness program, seminar/symposium, collaboration, social media, promotion, and outreach	clubsupport@ndl.gov.in
8	Digital Preservation Centre (DPC)	Assistance with digitizing and archiving copyright-free printed books	dpc@ndl.gov.in
9	IDR Setup or Support	Queries related to establishment and support of Institutional Digital Repository (IDR) and IDR workshops	idr@ndl.gov.in