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| Content Provider | PubMed Central |
|---|---|
| Author | Li, Xiao Li, Guoqi Wu, Shaoling Zhang, Baiyu Wan, Qing Yu, Ding Zhou, Ruijun Ma, Chao |
| Copyright Year | 2014 |
| Abstract | Human pheochromocytoma cells, which are demonstrated to contain and release met-enkephalin and norepinephrine, may be a promising resource for cell therapy in cancer-induced intractable pain. Intrathecal injection of alginate-poly (l) lysine-alginate (APA) microencapsulated human pheochromocytoma cells leads to antinociceptive effect in a rat model of bone cancer pain, and this effect was blocked by opioid antagonist naloxone and alpha 2-adrenergic antagonist rauwolscine. Neurochemical changes of cerebrospinal fluid are in accordance with the analgesic responses. Taken together, these data support that human pheochromocytoma cell implant-induced antinociception was mediated by met-enkephalin and norepinephrine secreted from the cell implants and acting at spinal receptors. Spinal implantation of microencapsulated human pheochromocytoma cells may provide an alternative approach for the therapy of chronic intractable pain. |
| Related Links | http://dx.doi.org/10.3390/ijms150712135 |
| Ending Page | 12148 |
| Starting Page | 12135 |
| File Format | |
| ISSN | 14220067 |
| e-ISSN | 14220067 |
| Journal | International Journal of Molecular Sciences |
| Issue Number | 7 |
| Volume Number | 15 |
| Language | English |
| Publisher | MDPI |
| Publisher Date | 2014-07-01 |
| Access Restriction | Open |
| Rights Holder | MDPI |
| Subject Keyword | Research in Higher Education |
| Content Type | Text |
| Resource Type | Article |
| Subject | Spectroscopy Organic Chemistry Medicine Molecular Biology Physical and Theoretical Chemistry Catalysis Inorganic Chemistry Computer Science Applications |
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