NDLI: Ventricular structure, function, and mechanics at high altitude: chronic remodeling in Sherpa vs. short-term lowlander adaptation

Content Provider	PubMed Central
Author	Stembridge, Mike Ainslie, Philip N. Hughes, Michael G. Stöhr, Eric J. Cotter, James D. Nio, Amanda Q. X. Shave, Rob
Copyright Year	2014
Abstract	Short-term, high-altitude (HA) exposure raises pulmonary artery systolic pressure (PASP) and decreases left-ventricular (LV) volumes. However, relatively little is known of the long-term cardiac consequences of prolonged exposure in Sherpa, a highly adapted HA population. To investigate short-term adaptation and potential long-term cardiac remodeling, we studied ventricular structure and function in Sherpa at 5,050 m (n = 11; 31 ± 13 yr; mass 68 ± 10 kg; height 169 ± 6 cm) and lowlanders at sea level (SL) and following 10 ± 3 days at 5,050 m (n = 9; 34 ± 7 yr; mass 82 ± 10 kg; height 177 ± 6 cm) using conventional and speckle-tracking echocardiography. At HA, PASP was higher in Sherpa and lowlanders compared with lowlanders at SL (both P < 0.05). Sherpa had smaller right-ventricular (RV) and LV stroke volumes than lowlanders at SL with lower RV systolic strain (P < 0.05) but similar LV systolic mechanics. In contrast to LV systolic mechanics, LV diastolic, untwisting velocity was significantly lower in Sherpa compared with lowlanders at both SL and HA. After partial acclimatization, lowlanders demonstrated no change in the RV end-diastolic area; however, both RV strain and LV end-diastolic volume were reduced. In conclusion, short-term hypoxia induced a reduction in RV systolic function that was also evident in Sherpa following chronic exposure. We propose that this was consequent to a persistently higher PASP. In contrast to the RV, remodeling of LV volumes and normalization of systolic mechanics indicate structural and functional adaptation to HA. However, altered LV diastolic relaxation after chronic hypoxic exposure may reflect differential remodeling of systolic and diastolic LV function.
Related Links	http://dx.doi.org/10.1152/japplphysiol.00233.2014
Ending Page	343
Page Count	10
Starting Page	334
File Format	PDF
ISSN	87507587
e-ISSN	15221601
Journal	Journal of Applied Physiology
Issue Number	3
Volume Number	117
Language	English
Publisher	American Physiological Society
Publisher Date	2014-08-01
Access Restriction	Open
Rights Holder	American Physiological Society
Subject Keyword	Physiology (medical) Physiology Research in Higher Education
Content Type	Text
Resource Type	Article
Subject	Physiology Physiology (medical) Sports Science

Sl.	Authority	Responsibilities	Communication Details
1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
2	Indian Institute of Technology Kharagpur	Host Institute of the Project: The host institute of the project is responsible for providing infrastructure support and hosting the project	https://www.iitkgp.ac.in
3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
5	Website/Portal (Helpdesk)	Queries regarding NDLI and its services	support@ndl.gov.in
6	Contents and Copyright Issues	Queries related to content curation and copyright issues	content@ndl.gov.in
7	National Digital Library of India Club (NDLI Club)	Queries related to NDLI Club formation, support, user awareness program, seminar/symposium, collaboration, social media, promotion, and outreach	clubsupport@ndl.gov.in
8	Digital Preservation Centre (DPC)	Assistance with digitizing and archiving copyright-free printed books	dpc@ndl.gov.in
9	IDR Setup or Support	Queries related to establishment and support of Institutional Digital Repository (IDR) and IDR workshops	idr@ndl.gov.in

Ventricular structure, function, and mechanics at high altitude: chronic remodeling in Sherpa vs. short-term lowlander adaptation.

Population History and Altitude-Related Adaptation in the Sherpa

Respiratory muscle fiber remodeling in chronic hyperinflation: dysfunction or adaptation?

Acetazolamide and cerebrovascular function at high altitude

Permanent alveolar remodeling in canine lung induced by high-altitude residence during maturation

Spleen Size and Function in Sherpa Living High, Sherpa Living Low and Nepalese Lowlanders

Taking vascular health to new heights: the short- and long-term impacts of altitude on cardiovascular function

Human placental metabolic adaptation to chronic hypoxia, high altitude: hypoxic preconditioning

Impaired myocardial function does not explain reduced left ventricular filling and stroke volume at rest or during exercise at high altitude.

Ventricular structure, function, and mechanics at high altitude: chronic remodeling in Sherpa vs. short-term lowlander adaptation

Similar Documents

Ventricular structure, function, and mechanics at high altitude: chronic remodeling in Sherpa vs. short-term lowlander adaptation.

Population History and Altitude-Related Adaptation in the Sherpa

Respiratory muscle fiber remodeling in chronic hyperinflation: dysfunction or adaptation?

Acetazolamide and cerebrovascular function at high altitude

Permanent alveolar remodeling in canine lung induced by high-altitude residence during maturation

Spleen Size and Function in Sherpa Living High, Sherpa Living Low and Nepalese Lowlanders

Taking vascular health to new heights: the short- and long-term impacts of altitude on cardiovascular function

Human placental metabolic adaptation to chronic hypoxia, high altitude: hypoxic preconditioning

Impaired myocardial function does not explain reduced left ventricular filling and stroke volume at rest or during exercise at high altitude.

Ventricular structure, function, and mechanics at high altitude: chronic remodeling in Sherpa vs. short-term lowlander adaptation