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| Content Provider | PubMed Central |
|---|---|
| Author | Chen, Xiaoke Zheng, Yonghua Manole, Catalin G. Wang, Xiangdong Wang, Qun |
| Copyright Year | 2013 |
| Abstract | Telocytes (TCs), a new type of interstitial cells, were identified in many different organs and tissues of mammalians and humans. In this study, we show the presence, in human oesophagus, of cells having the typical features of TCs in lamina propria of the mucosa, as well as in muscular layers. We used transmission electron microscopy (TEM), immunohistochemistry (IHC) and primary cell culture. Human oesophageal TCs present a small cell body with 2–3 very long Telopodes (Tps). Tps consist of an alternation of thin segments (podomers) and thick segments (podoms) and have a labyrinthine spatial arrangement. Tps establish close contacts (‘stromal synapses’) with other neighbouring cells (e.g. lymphocytes, macrophages). The ELISA testing of the supernatant of primary culture of TCs indicated that the concentrations of VEGF and EGF increased progressively. In conclusion, our study shows the existence of typical TCs at the level of oesophagus (mucosa, submucosa and muscular layer) and suggests their possible role in tissue repair. |
| Related Links | http://dx.doi.org/10.1111/jcmm.12149 |
| Ending Page | 1512 |
| Page Count | 7 |
| Starting Page | 1506 |
| File Format | |
| ISSN | 15824934 |
| e-ISSN | 15824934 |
| Journal | Journal of Cellular and Molecular Medicine |
| Issue Number | 11 |
| Volume Number | 17 |
| Language | English |
| Publisher | John Wiley & Sons |
| Publisher Date | 2013-11-01 |
| Access Restriction | Open |
| Rights Holder | John Wiley & Sons |
| Subject Keyword | Research in Higher Education |
| Content Type | Text |
| Resource Type | Article |
| Subject | Cell Biology Molecular Medicine |
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