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Catch and Release: Photocleavable Cationic Diblock Copolymers as a Potential Platform for Nucleic Acid Delivery
| Content Provider | PubMed Central |
|---|---|
| Author | Green, Matthew D. Foster, Abbygail A. Greco, Chad T. Roy, Raghunath Lehr, Rachel M. Epps, Thomas H. Sullivan, Millicent O. |
| Copyright Year | 2012 |
| Abstract | Binding interactions between DNA and cationic carriers must be sufficiently strong to prevent nuclease-mediated degradation, yet weak enough to permit transcription. We demonstrate cationic diblock copolymers containing PEG and o-nitrobenzyl moieties that facilitated tailorable DNA complexation and light-activated release. This design unlocks a new approach to advance non-viral gene packaging. |
| Related Links | http://dx.doi.org/10.1039/c4py00638k |
| File Format | |
| ISSN | 17599954 |
| e-ISSN | 17599962 |
| Journal | Polymer chemistry |
| Language | English |
| Publisher Date | 2014-01-01 |
| Access Restriction | Open |
| Subject Keyword | Organic Chemistry Biochemistry Bioengineering Polymers and Plastics Biomedical Engineering Research in Higher Education |
| Content Type | Text |
| Resource Type | Article |
| Subject | Organic Chemistry Biochemistry Bioengineering Biomedical Engineering Polymers and Plastics |