NDLI: Strategies for Designing and Monitoring Malaria Vaccines Targeting Diverse Antigens

Content Provider	PubMed Central
Author	Barry, Alyssa E. Arnott, Alicia
Copyright Year	2014
Abstract	After more than 50 years of intensive research and development, only one malaria vaccine candidate, “RTS,S,” has progressed to Phase 3 clinical trials. Despite only partial efficacy, this candidate is now forecast to become the first licensed malaria vaccine. Hence, more efficacious second-generation malaria vaccines that can significantly reduce transmission are urgently needed. This review will focus on a major obstacle hindering development of effective malaria vaccines: parasite antigenic diversity. Despite extensive genetic diversity in leading candidate antigens, vaccines have been and continue to be formulated using recombinant antigens representing only one or two strains. These vaccine strains represent only a small fraction of the diversity circulating in natural parasite populations, leading to escape of non-vaccine strains and challenging investigators’ abilities to measure strain-specific efficacy in vaccine trials. Novel strategies are needed to overcome antigenic diversity in order for vaccine development to succeed. Many studies have now cataloged the global diversity of leading Plasmodium falciparum and Plasmodium vivax vaccine antigens. In this review, we describe how population genetic approaches can be applied to this rich data source to predict the alleles that best represent antigenic diversity, polymorphisms that contribute to it, and to identify key polymorphisms associated with antigenic escape. We also suggest an approach to summarize the known global diversity of a given antigen to predict antigenic diversity, how to select variants that best represent the strains circulating in natural parasite populations and how to investigate the strain-specific efficacy of vaccine trials. Use of these strategies in the design and monitoring of vaccine trials will not only shed light on the contribution of genetic diversity to the antigenic diversity of malaria, but will also maximize the potential of future malaria vaccine candidates.
Related Links	http://dx.doi.org/10.3389/fimmu.2014.00359
Starting Page	359
File Format	PDF
ISSN	16643224
e-ISSN	16643224
Journal	Frontiers in Immunology
Volume Number	5
Language	English
Publisher	Frontiers Media S.A.
Publisher Date	2014-07-28
Access Restriction	Open
Rights Holder	Frontiers Media S.A.
Subject Keyword	Research in Higher Education
Content Type	Text
Resource Type	Article
Subject	Immunology and Allergy Immunology

Sl.	Authority	Responsibilities	Communication Details
1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
2	Indian Institute of Technology Kharagpur	Host Institute of the Project: The host institute of the project is responsible for providing infrastructure support and hosting the project	https://www.iitkgp.ac.in
3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
5	Website/Portal (Helpdesk)	Queries regarding NDLI and its services	support@ndl.gov.in
6	Contents and Copyright Issues	Queries related to content curation and copyright issues	content@ndl.gov.in
7	National Digital Library of India Club (NDLI Club)	Queries related to NDLI Club formation, support, user awareness program, seminar/symposium, collaboration, social media, promotion, and outreach	clubsupport@ndl.gov.in
8	Digital Preservation Centre (DPC)	Assistance with digitizing and archiving copyright-free printed books	dpc@ndl.gov.in
9	IDR Setup or Support	Queries related to establishment and support of Institutional Digital Repository (IDR) and IDR workshops	idr@ndl.gov.in

Strategies for designing and monitoring malaria vaccines targeting diverse antigens

Targeting and utilizing primary tumors as live vaccines: changing strategies

DNA vaccines: designing strategies against parasitic infections

Antigens for pre-erythrocytic malaria vaccines: building on success

Designing Vaccines for the Twenty-First Century Society

Cancer targeting vaccines

Plasmodium vivax malaria vaccines

Building better T-cell-inducing malaria vaccines

Targeting Human Dendritic Cell Subsets for Improved Vaccines

Strategies for Designing and Monitoring Malaria Vaccines Targeting Diverse Antigens

Similar Documents

Strategies for designing and monitoring malaria vaccines targeting diverse antigens

Targeting and utilizing primary tumors as live vaccines: changing strategies

DNA vaccines: designing strategies against parasitic infections

Antigens for pre-erythrocytic malaria vaccines: building on success

Designing Vaccines for the Twenty-First Century Society

Cancer targeting vaccines

Plasmodium vivax malaria vaccines

Building better T-cell-inducing malaria vaccines

Targeting Human Dendritic Cell Subsets for Improved Vaccines

Strategies for Designing and Monitoring Malaria Vaccines Targeting Diverse Antigens