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Reinforcing Silk Scaffolds with Silk Particles
| Content Provider | PubMed Central |
|---|---|
| Author | Rajkhowa, Rangam Gil, Eun Seok Kluge, Jonathan Numata, Keiji Wang, Lijing Wang, Xungai Kaplan, David L. |
| Copyright Year | 2010 |
| Abstract | Silk fibroin is a useful protein polymer for biomaterials and tissue engineering. In this work, porogen leached scaffolds prepared from aqueous and HFIP silk solutions were reinforced through the addition of silk particles. This led to about 40 times increase in the specific compressive modulus and the yield strength of HFIP-based scaffolds. This increase in mechanical properties resulted from the high interfacial cohesion between the silk matrix and the reinforcing silk particles, due to partial solubility of the silk particles in HFIP. The porosity of scaffolds was reduced from ≈90% (control) to ≈75% for the HFIP systems containing 200% particle reinforcement, while maintaining pore interconnectivity. The presence of the particles slowed the enzymatic degradation of silk scaffolds. |
| Related Links | http://dx.doi.org/10.1002/mabi.200900358 |
| Ending Page | 611 |
| Page Count | 13 |
| Starting Page | 599 |
| File Format | |
| ISSN | 16165187 |
| e-ISSN | 16165195 |
| Journal | Macromolecular bioscience |
| Issue Number | 6 |
| Volume Number | 10 |
| Language | English |
| Publisher Date | 2010-06-01 |
| Access Restriction | Open |
| Subject Keyword | Biotechnology Materials Chemistry Bioengineering Polymers and Plastics Biomaterials Research in Higher Education |
| Content Type | Text |
| Resource Type | Article |
| Subject | Materials Chemistry Biomaterials Bioengineering Biotechnology Polymers and Plastics |
