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  1. Pain and Therapy
  2. Year: 2013, Volume: 2
  3. Year: 2013, Volume: 2, Issue: 1
  4. Fentanyl Sublingual Spray for Breakthrough Pain in Cancer Patients
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Year: 2015, Volume: 4
Year: 2014, Volume: 3
Year: 2013, Volume: 2
Year: 2013, Volume: 2, Issue: 2
Year: 2013, Volume: 2, Issue: 1
Fentanyl Sublingual Spray for Breakthrough Pain in Cancer Patients
Review of Lidocaine/Tetracaine Cream as a Topical Anesthetic for Dermatologic Laser Procedures
Myofascial Pain Syndrome: A Treatment Review
Randomized Study of Pregabalin in Patients with Cancer-Induced Bone Pain
Predictive Value of Lidocaine for Treatment Success of Oxcarbazepine in Patients with Neuropathic Pain Syndrome
Effects of a Single Session Group Intervention for Pain Management in Chronic Pain Patients: A Pilot Study
Interpreting Effect Sizes and Clinical Relevance of Pharmacological Interventions for Fibromyalgia
Erratum to: Review of Lidocaine/Tetracaine Cream as a Topical Anesthetic for Dermatologic Laser Procedures
Year: 2012, Volume: 1

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Fentanyl Sublingual Spray for Breakthrough Pain in Cancer Patients

Content Provider PubMed Central
Author Zeppetella, Giovambattista
Abstract Breakthrough pain is a transient exacerbation of pain that occurs either spontaneously, or in relation to a specific predictable or unpredictable trigger, despite relatively stable and adequately controlled background pain. Typically, breakthrough pain has a fast onset and short duration, and a significant impact on patients’ quality of life. Normal-release oral opioids are the traditional pharmacological approach for patients who are receiving an around the clock opioid regimen; however, their onset and duration of action may not be suitable for treating many breakthrough pains. Efforts to provide nonparenteral opioid formulations that could provide more rapid, and more effective, relief of breakthrough pain have led to the development of transmucosal opioid formulations including fentanyl sublingual spray (FSLS). This is a formulation of fentanyl available in doses of 100, 200, 400, 600, and 800 μg strengths approved for the management of breakthrough pain in adult cancer patients already receiving and who are tolerant to opioid therapy for their underlying persistent cancer pain. Published pharmacokinetic, efficacy, tolerability, and safety data suggest that FSLS has a valuable role to play in the symptomatic pharmacological management of breakthrough pain. The effective dose of FSLS is determined by titration according to the needs of the individual patient.
Related Links http://dx.doi.org/10.1007/s40122-013-0008-9
Starting Page 1
File Format PDF
ISSN 2193651X
e-ISSN 2193651X
Journal Pain and Therapy
Issue Number 1
Volume Number 2
Language English
Publisher Springer Healthcare
Publisher Date 2013-06-01
Access Restriction Open
Rights Holder Springer Healthcare
Subject Keyword Research in Higher Education
Content Type Text
Resource Type Article
Subject Neurology (clinical) Anesthesiology and Pain Medicine
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