NDLI: Innate immunity to influenza virus infection

Content Provider	PubMed Central
Author	Iwasaki, Akiko Pillai, Padmini S.
Abstract	Influenza viruses are a major pathogen of both humans and animals. Recent studies using gene-knockout mice have led to an in-depth understanding of the innate sensors that detect influenza virus infection in a variety of cell types. Signalling downstream of these sensors induces distinct sets of effector mechanisms that block virus replication and promote viral clearance by inducing innate and adaptive immune responses. In this Review, we discuss the various ways in which the innate immune system uses pattern recognition receptors to detect and respond to influenza virus infection. We consider whether the outcome of innate sensor stimulation promotes antiviral resistance or disease tolerance, and propose rational treatment strategies for the acute respiratory disease that is caused by influenza virus infection.
Related Links	http://dx.doi.org/10.1038/nri3665
Ending Page	328
Page Count	14
Starting Page	315
File Format	PDF
ISSN	14741733
e-ISSN	14741741
Journal	Nature reviews. Immunology
Issue Number	5
Volume Number	14
Language	English
Publisher Date	2014-04-01
Access Restriction	Open
Subject Keyword	Immunology Research in Higher Education
Content Type	Text
Resource Type	Article
Subject	Immunology and Allergy Immunology

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1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
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4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
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Innate immunity to influenza virus infection