NDLI: Interleukin-7 receptor-α gene mutations are not detected in adult T-cell acute lymphoblastic leukemia

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Year: 2014, Volume: 3, Issue: 2

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Interleukin-7 receptor-α gene mutations are not detected in adult T-cell acute lymphoblastic leukemia

Content Provider	PubMed Central
Author	Uri, Rozovski Ping, Li Harris, David Ohanian, Maro Hagop, Kantarjian Zeev, Estrov
Copyright Year	2014
Abstract	Somatic mutations in cancer cell genes are classified according to their functional significance. Those that provide the malignant cells with significant advantage are collectively referred to as driver mutations and those that do not, are the passenger mutations. Accordingly, analytical criteria to distinguish driver mutations from passenger mutations have been recently suggested. Recent studies revealed mutations in interleukin-7 receptor-α (IL7R) gene in 10% of pediatric T-cell acute lymphoblastic leukemia (T-ALL) patients and in only a few cases of pediatric B-ALL. IL7R mutations are also frequently found in patients with lung cancer, but whereas in pediatric T-ALL IL7R mutations are “drivers” (consisting of gain-of-function mutations within a narrow 50-base pair interval at exon 6 that confer cytokine-independent cell growth and promote tumor transformation), in lung cancer, mutations are substitution mutations randomly distributed across the gene and are probably only “passenger” events. Because the treatment response of adult T-ALL is significantly poorer than that of childhood T-ALL and because exon 6 IL7R mutations play a role in the pathogenesis of childhood T-ALL, we sought to determine how the pattern of IL7R mutations varies between adult and childhood T-ALL. To that end, we sequenced the 50-base pair interval in exon 6 of the IL7R of DNA obtained from bone marrow samples of 35 randomly selected adult patients with T-ALL. Our analysis revealed that none of these 35 samples carried an IL7R mutation in exon 6. Whether differences in the genetic makeup of adult and childhood T-ALL explain the differential response to therapy remains to be determined.
Related Links	http://dx.doi.org/10.1002/cam4.194
Ending Page	554
Page Count	5
Starting Page	550
File Format	PDF
ISSN	20457634
e-ISSN	20457634
Journal	Cancer Medicine
Issue Number	3
Volume Number	3
Language	English
Publisher	BlackWell Publishing Ltd
Publisher Date	2014-06-01
Access Restriction	Open
Rights Holder	BlackWell Publishing Ltd
Subject Keyword	Research in Higher Education
Content Type	Text
Resource Type	Article
Subject	Radiology, Nuclear Medicine and Imaging Cancer Research Oncology

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