NDLI: Ventromedial prefrontal cortex and the regulation of physiological arousal

Content Provider	PubMed Central
Author	Zhang, Sheng Hu, Sien Chao, Herta H. Ide, Jaime S. Luo, Xi Farr, Olivia M. Li, Chiang-shan R.
Copyright Year	2013
Abstract	Neuroimaging studies show a correlation between activity of the ventromedial prefrontal cortex (vmPFC) and skin conductance measurements. However, little is known whether this brain region plays a causal role in regulating physiological arousal. To address this question, we employed Granger causality analysis (GCA) to establish causality between cerebral blood oxygenation level-dependent and skin conductance signals in 24 healthy adults performing a cognitive task during functional magnetic resonance imaging. The results showed that activity of the vmPFC not only negatively correlated with skin conductance level (SCL) but also Granger caused SCL, thus establishing the direction of influence. Importantly, across participants, the strength of Granger causality was negatively correlated to phasic skin conductance responses elicited by external events during the behavioral task. In contrast, activity of the dorsal anterior cingulate cortex positively correlated with SCL but did not show a causal relationship in GCA. These new findings indicate that the vmPFC plays a causal role in regulating physiological arousal. Increased vmPFC activity leads to a decrease in skin conductance. The findings may also advance our understanding of dysfunctions of the vmPFC in mood and anxiety disorders that involve altered control of physiological arousal.
Related Links	http://dx.doi.org/10.1093/scan/nst064
Ending Page	908
Page Count	9
Starting Page	900
File Format	PDF
ISSN	17495016
e-ISSN	17495024
Journal	Social Cognitive and Affective Neuroscience
Issue Number	7
Volume Number	9
Language	English
Publisher	Oxford University Press
Publisher Date	2014-07-01
Access Restriction	Open
Rights Holder	Oxford University Press
Subject Keyword	Experimental and Cognitive Psychology Cognitive Neuroscience Research in Higher Education
Content Type	Text
Resource Type	Article
Subject	Experimental and Cognitive Psychology Cognitive Neuroscience Medicine

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4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
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