NDLI: Toll-like receptor 4 signaling contributes to paclitaxel-induced peripheral neuropathy

Content Provider	PubMed Central
Author	Yan, Li Zhang, Haijun Zhang, Hongmei Kosturakis, Alyssa K. Jawad, Abdul Basit Dougherty, Patrick M.
Copyright Year	2014
Abstract	This paper tests the contribution of the toll-like receptors (TLRs), TLR4 in particular, in the initiation and maintenance of paclitaxel-related chemotherapy-induced peripheral neuropathy (CIPN). TLR4 and its immediate down-stream signaling molecules MyD88 and TRIF were increased in dorsal root ganglion (DRG) by western blot by day 7 of paclitaxel treatment. The behavioral phenotype, the increase of both TLR4 and MyD88 was blocked by co-treatment with the TLR4 antagonist LPS-RS during chemotherapy. A similar, but less robust behavioral effect was observed using intrathecal treatment of MyD88 homodimerization inhibitory peptide. DRG levels of TLR4 and MyD88 reduced over the next two weeks, whereas these levels remained increased in spinal cord through day 21 following chemotherapy. Immunohistochemical analysis revealed TLR4 expression in both CGRP- and IB4-positive small DRG neurons. MyD88 was only found in CGRP-positive neurons and TRIF was found both in CGRP- and IB4-positive small DRG neurons as well as in medium and large size DRG neurons. In spinal cord TLR4 was only found co-localized to astrocytes but not with either microglia or neurons. Intrathecal treatment with the TLR4 antagonist lipopolysaccharide-RS (LPS-RS) transiently reversed pre-established CIPN mechanical hypersensitivity. These results strongly implicate TLR4 signaling in DRG and spinal cord in the induction and maintenance of paclitaxel related CIPN.
Related Links	http://dx.doi.org/10.1016/j.jpain.2014.04.001
Ending Page	725
Page Count	14
Starting Page	712
File Format	PDF
ISSN	15265900
e-ISSN	15288447
Journal	The journal of pain : official journal of the American Pain Society
Issue Number	7
Volume Number	15
Language	English
Publisher Date	2014-07-01
Access Restriction	Open
Subject Keyword	Anesthesiology and Pain Medicine Neurology Clinical Neurology Research in Higher Education
Content Type	Text
Resource Type	Article
Subject	Neurology Neurology (clinical) Anesthesiology and Pain Medicine

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