NDLI: Molecular composition of the alveolar lining fluid in the aging lung

Content Provider	PubMed Central
Author	Moliva, Juan I. Rajaram, Murugesan V. S. Sidiki, Sabeen Sasindran, Smitha J. Guirado, Evelyn Pan, Xueliang Jeff Wang, Shu-hua Ross, Patrick Lafuse, William P. Schlesinger, Larry S. Turner, Joanne Torrelles, Jordi B.
Abstract	As we age, there is an increased risk for the development of pulmonary diseases, including infections, but few studies have considered changes in lung surfactant and components of the innate immune system as contributing factors to the increased susceptibility of the elderly to succumb to infections. We and others have demonstrated that human alveolar lining fluid (ALF) components, such as surfactant protein (SP)-A, SP-D, complement protein C3, and alveolar hydrolases, play a significant innate immune role in controlling microbial infections. However, there is a lack of information regarding the effect of increasing age on the level and function of ALF components in the lung. Here we addressed this gap in knowledge by determining the levels of ALF components in the aging lung that are important in controlling infection. Our findings demonstrate that pro-inflammatory cytokines, surfactant proteins and lipids, and complement components are significantly altered in the aged lung in both mice and humans. Further, we show that the aging lung is a relatively oxidized environment. Our study provides new information on how the pulmonary environment in old age can potentially modify mucosal immune responses, thereby impacting pulmonary infections and other pulmonary diseases in the elderly population.
Related Links	http://dx.doi.org/10.1007/s11357-014-9633-4
Starting Page	9633
File Format	PDF
ISSN	01619152
e-ISSN	15744647
Journal	Age
Issue Number	3
Volume Number	36
Language	English
Publisher	Springer Netherlands
Publisher Date	2014-06-01
Access Restriction	Open
Rights Holder	Springer Netherlands
Subject Keyword	Ageing Geriatrics and Gerontology Research in Higher Education
Content Type	Text
Resource Type	Article
Subject	Aging Geriatrics and Gerontology

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