NDLI: Genetic shifting: a novel approach for controlling vector-borne diseases

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Genetic shifting: a novel approach for controlling vector-borne diseases

Content Provider	PubMed Central
Author	Powell, Jeffrey R. Tabachnick, Walter J.
Copyright Year	2014
Abstract	Rendering populations of vectors of diseases incapable of transmitting pathogens through genetic methods has long been a goal of vector geneticists. We outline a method to achieve this goal that does not involve introduction of any new genetic variants to the target population. Rather we propose that shifting the frequencies of naturally occurring alleles that confer refractoriness to transmission can reduce transmission below a sustainable level. The program employs methods successfully used in plant and animal breeding. Because no artificially constructed genetically modified organisms (GMOs) are introduced into the environment, the method is minimally controversial. We use Aedes aegypti and dengue virus (DENV) for illustrative purposes, but point out the proposed program is generally applicable to vector-borne disease control.
Related Links	http://dx.doi.org/10.1016/j.pt.2014.04.005
Ending Page	288
Page Count	7
Starting Page	282
File Format	PDF
ISSN	14714922
e-ISSN	14715007
Journal	Trends in parasitology
Issue Number	6
Volume Number	30
Language	English
Publisher Date	2014-06-01
Access Restriction	Open
Subject Keyword	Parasitology Infectious Diseases Research in Higher Education
Content Type	Text
Resource Type	Article
Subject	Infectious Diseases Parasitology

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