NDLI: Chip Based Single Cell Analysis for Nanotoxicity Assessment

Content Provider	PubMed Central
Author	Shah, Pratikkumar Kaushik, Ajeet Zhu, Xuena Zhang, Chengxiao Li, Chen-zhong
Abstract	Nanomaterials, because of their tunable properties and performances, have been utilized extensively in everyday life related consumable products and technology. On exposure, beyond physiological range, nanomaterials cause health risks via affecting the function of organisms, genomic systems, and even central nervous system. Thus, new analytical approaches for nanotoxicity assessment to verify the feasibility of nanomaterials for future use are in demand. The conventional analytical techniques, such as spectrophotometric assay-based techniques usually require a lengthy and time-consuming process and many times produces false positives, and many times cannot be implemented at a single cell level measurement for studying cell behavior without interference of their surrounding environment. Hence, there is demand of a precise, accurate, sensitive assessment for toxicity using single cell. Recently, due to advantages of automation of fluids and minimization of human error, the integration of cell-on-a-chip (CoC) with microfluidic system is in practice for nanotoxicity assessments. This review explains nanotoxicity and assessment approaches with advantages/limitations and new approaches to overcome the confines of traditional techniques. Recent advances in nanotoxicity assessment using CoC integrated with microfluidic system are also discussed in this review, which may be of use for nanotoxicity assessment and diagnostics.
Related Links	http://dx.doi.org/10.1039/c3an02280c
Ending Page	2098
Page Count	11
Starting Page	2088
File Format	PDF
ISSN	00032654
e-ISSN	13645528
Journal	The Analyst
Issue Number	9
Volume Number	139
Language	English
Publisher Date	2014-01-01
Access Restriction	Open
Subject Keyword	Analytical Chemistry Spectroscopy Electrochemistry Biochemistry Environmental Chemistry Research in Higher Education
Content Type	Text
Resource Type	Article
Subject	Spectroscopy Environmental Chemistry Analytical Chemistry Biochemistry Electrochemistry

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