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| Content Provider | PubMed Central |
|---|---|
| Author | Sharma, Manish Farhad, Ravandi Bayraktar, Ulas Darda Alexandre, Chiattone Bashir, Qaiser Giralt, Sergio Chen, Julianne Muzaffar, Qazilbash Partow, Kebriaei Marina, Konopleva Andreeff, Michael Cortes, Jorge Mccue, Deborah Hagop, Kantarjian Champlin, Richard E. Lima, Marcos De |
| Copyright Year | 2011 |
| Abstract | Patients with acute myeloid leukemia (AML) and internal tandem duplication of FMS-like tyrosine kinase receptor-3 gene (FLT3-ITD) mutation have poor prognoses and are often treated with allogeneic hematopoietic stem cell transplantation (HSCT). Sorafenib, an inhibitor of multiple kinases including FLT3, has shown promising activity in FLT3-ITD-positive AML. We treated 16 patients with FLT3-ITD-positive AML who relapsed after HSCT with sorafenib alone (n = 8) or in combination with cytotoxic chemotherapy (n = 8). The number of circulating blasts decreased in 80% of cases, but none of the patients achieved complete remission (CR); 3 achieved partial remission. Two patients were bridged to a second transplantation but both relapsed within 3 months of the transplantation. Median overall survival (OS) was 83 days, with none surviving more than a year. Sorafenib is not effective in the treatment of FLT3-ITD-positive AML relapsing after HSCT. Preventive strategies after HSCT may be more suitable for these high-risk patients. |
| Related Links | http://dx.doi.org/10.1016/j.bbmt.2011.07.011 |
| Ending Page | 1877 |
| Page Count | 4 |
| Starting Page | 1874 |
| File Format | |
| ISSN | 10838791 |
| e-ISSN | 15236536 |
| Journal | Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation |
| Issue Number | 12 |
| Volume Number | 17 |
| Language | English |
| Publisher Date | 2011-12-01 |
| Access Restriction | Open |
| Subject Keyword | Transplantation Hematology Research in Higher Education |
| Content Type | Text |
| Resource Type | Article |
| Subject | Hematology Transplantation |
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