NDLI: Subchondral bone in osteoarthritis: insight into risk factors and microstructuralchanges

Content Provider	PubMed Central
Author	Li, Guangyi Yin, Jimin Gao, Junjie Cheng, Tak S. Pavlos, Nathan J. Zhang, Changqing Zheng, Ming H.
Copyright Year	2013
Abstract	Osteoarthritis (OA) is a major cause of disability in the adult population. As aprogressive degenerative joint disorder, OA is characterized by cartilage damage,changes in the subchondral bone, osteophyte formation, muscle weakness, andinflammation of the synovium tissue and tendon. Although OA has long been viewed as aprimary disorder of articular cartilage, subchondral bone is attracting increasingattention. It is commonly reported to play a vital role in the pathogenesis of OA.Subchondral bone sclerosis, together with progressive cartilage degradation, iswidely considered as a hallmark of OA. Despite the increase in bone volume fraction,subchondral bone is hypomineralized, due to abnormal bone remodeling. Somehistopathological changes in the subchondral bone have also been detected, includingmicrodamage, bone marrow edema-like lesions and bone cysts. This review summarizesbasic features of the osteochondral junction, which comprises subchondral bone andarticular cartilage. Importantly, we discuss risk factors influencing subchondralbone integrity. We also focus on the microarchitectural and histopathological changesof subchondral bone in OA, and provide an overview of their potential contribution tothe progression of OA. A hypothetical model for the pathogenesis of OA isproposed.
Related Links	http://dx.doi.org/10.1186/ar4405
Starting Page	223
File Format	PDF
ISSN	14786354
e-ISSN	14786362
Journal	Arthritis Research & Therapy
Issue Number	6
Volume Number	15
Language	English
Publisher	BioMed Central
Publisher Date	2013-01-01
Access Restriction	Open
Rights Holder	BioMed Central
Subject Keyword	Immunology Immunology and Allergy Rheumatology Research in Higher Education
Content Type	Text
Resource Type	Article
Subject	Immunology and Allergy Immunology Rheumatology

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