NDLI: Immune-mediated animal models of Tourette syndrome

Content Provider	PubMed Central
Author	Hornig, Mady Lipkin, W. Ian
Copyright Year	2013
Abstract	An autoimmune diathesis has been proposed in Tourette syndrome (TS) and related neuropsychiatric disorders such as obsessive-compulsive disorder, attention-deficit/hyperactivity disorder, autism and anorexia nervosa. Environmental triggers including infection and xenobiotics are hypothesized to lead to the production of brain-directed autoantibodies in a subset of genetically susceptible individuals. Although much work has focused on Group A Streptococcus (GAS), the role of this common childhood infection remains controversial. Animal model studies based on immune and autoantibody findings in TS have demonstrated immunoglobulin (Ig) deposits and stereotypic movements and related behavioral disturbances reminiscent of TS following exposure to GAS and other activators of host anti-microbial responses, soluble immune mediators and anti-GAS or anti-neuronal antibodies. Demonstration of the ability to recreate these abnormalities through passive transfer of serum IgG from GAS-immunized mice into naïve mice and abrogation of this activity through depletion of IgG has provided compelling evidence in support of the autoimmune hypothesis. Immunologically-based animal models of TS are a potent tool for dissecting the pathogenesis of this serious neuropsychiatric syndrome.
Related Links	http://dx.doi.org/10.1016/j.neubiorev.2013.01.007
Ending Page	1138
Page Count	19
Starting Page	1120
File Format	PDF
ISSN	01497634
e-ISSN	18737528
Journal	Neuroscience and biobehavioral reviews
Issue Number	6
Volume Number	37
Language	English
Publisher Date	2013-07-01
Access Restriction	Open
Subject Keyword	Cognitive Neuroscience Behavioral Neuroscience Neuropsychology and Physiological Psychology Research in Higher Education
Content Type	Text
Resource Type	Article
Subject	Cognitive Neuroscience Behavioral Neuroscience Neuropsychology and Physiological Psychology

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