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| Content Provider | PubMed Central |
|---|---|
| Author | Upadhyay, Ghanshyam Chowdhury, Asif H. Vaidyanathan, Bharat Kim, David Saleque, Shireen |
| Abstract | This work illustrates the dual regulation of the potent and widely expressed demethylase lysine-specific demethylase 1 (LSD1) by the antagonistic actions of stimulatory and inhibitory Rcor factors and their consequences on hematopoietic differentiation. Given the crucial role of LSD1 in diverse developmental contexts, including ES cells, multiple mammalian tissues, and oncogenesis, these results could potentially reflect the function of LSD1 and Rcor1-3 in multiple normal and aberrant developmental contexts. Moreover, these insights could be used to develop targeted strategies for controlling LSD1 activity in different diseases. |
| Related Links | http://dx.doi.org/10.1073/pnas.1404292111 |
| Ending Page | 8076 |
| Page Count | 6 |
| Starting Page | 8071 |
| File Format | |
| ISSN | 00278424 |
| e-ISSN | 10916490 |
| Journal | Proceedings of the National Academy of Sciences of the United States of America |
| Issue Number | 22 |
| Volume Number | 111 |
| Language | English |
| Publisher | National Academy of Sciences |
| Publisher Date | 2014-06-03 |
| Access Restriction | Open |
| Rights Holder | National Academy of Sciences |
| Subject Keyword | General Research in Higher Education |
| Content Type | Text |
| Resource Type | Article |
| Subject | Multidisciplinary |
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