NDLI: Signal Processing and Flagellar Motor Switching During Phototaxis of Halobacterium salinarum

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Signal Processing and Flagellar Motor Switching During Phototaxis of Halobacterium salinarum

Content Provider	PubMed Central
Author	Nutsch, Torsten Marwan, Wolfgang Dieter, Oesterhelt Gilles, Ernst Dieter
Copyright Year	2003
Abstract	Prokaryotic taxis, the active search of motile cells for the best environmental conditions, is one of the paradigms for signal transduction. The search algorithm implemented by the cellular biochemistry modulates the probability of switching the rotational direction of the flagellar motor, a nanomachine that propels prokaryotic cells. On the basis of the well-known biochemical mechanisms of chemotaxis in Escherichia coli, kinetic modeling of the events leading from chemoreceptor activation by ligand binding to the motility response has been performed with great success. In contrast to Escherichia coli, Halobacterium salinarum, in addition, responds to visible light, which is sensed through specific photoreceptors of different wavelength sensitivity (phototaxis). Light stimuli of defined intensity and time course can be controlled precisely, which facilitates input-output measurements used for system analysis of the molecular network connecting the sensory receptors to the flagellar motor switch. Here, we analyze the response of halobacterial cells to single and double-pulse light stimuli and present the first kinetic model for prokaryotic cells that couples the signal-transduction pathway with the flagellar motor switch. Modeling based on experimental data supports the current biochemical model of halobacterial phototaxis. Moreover, the simulations demonstrate that motor switching occurs through subsequent rate-limiting steps, which are both under sensory control, suggesting that two signals may be involved in halobacterial phototaxis.
Related Links	http://dx.doi.org/10.1101/gr.1241903
Starting Page	2406
File Format	PDF
ISSN	10889051
Journal	Genome Research
Issue Number	11
Volume Number	13
Language	English
Publisher	Cold Spring Harbor Laboratory Press
Publisher Date	2003-11-01
Access Restriction	Open
Rights Holder	Cold Spring Harbor Laboratory Press
Subject Keyword	Research in Higher Education
Content Type	Text
Resource Type	Article
Subject	Genetics Genetics (clinical)

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