NDLI: NK cell therapy: targeting disease relapse after hematopoietic stem cell transplantation

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NK cell therapy: targeting disease relapse after hematopoietic stem cell transplantation

Content Provider	PubMed Central
Author	Farhan, Shatha Lee, Dean A. Champlin, Richard E. Ciurea, Stefan O.
Abstract	As outcomes of hematopoietic stem cell transplantation have improved over time, disease relapse has emerged as the most important causes of treatment failure. Cellular therapy represents a promising therapeutic approach, not only to treat or prevent disease relapse after hematopoietic stem cell transplantation, but also conceivably to help patients achieve remission prior to transplantation or as consolidation therapy for high risk hematologic malignancies. Of the many cellular therapies available, NK cells infusion may be the most promising approach due to strong innate activity of NK cells in vitro and in vivo against malignant or virally infected cells. Published clinical data consists only of small feasibility studies of inadequate size to show clinical benefit. Here we review the current status of clinical investigation using NK cell therapy for patients with hematologic malignancies undergoing hematopoietic stem cell transplantation.
Related Links	http://dx.doi.org/10.2217/imt.11.174
Ending Page	313
Page Count	9
Starting Page	305
File Format	PDF
ISSN	17507448
e-ISSN	17507448
Journal	Immunotherapy
Issue Number	3
Volume Number	4
Language	English
Publisher Date	2012-03-01
Access Restriction	Open
Subject Keyword	Research in Higher Education
Content Type	Text
Resource Type	Article
Subject	Immunology and Allergy Immunology Oncology

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