NDLI: Extraction and restoration of hippocampal spatial memories with non-linear dynamical modeling

Content Provider	PubMed Central
Author	Song, Dong Madhuri, Harway Marmarelis, Vasilis Z. Hampson, Robert E. Deadwyler, Sam A. Berger, Theodore W.
Copyright Year	2014
Abstract	To build a cognitive prosthesis that can replace the memory function of the hippocampus, it is essential to model the input-output function of the damaged hippocampal region, so the prosthetic device can stimulate the downstream hippocampal region, e.g., CA1, with the output signal, e.g., CA1 spike trains, predicted from the ongoing input signal, e.g., CA3 spike trains, and the identified input-output function, e.g., CA3-CA1 model. In order for the downstream region to form appropriate long-term memories based on the restored output signal, furthermore, the output signal should contain sufficient information about the memories that the animal has formed. In this study, we verify this premise by applying regression and classification modelings of the spatio-temporal patterns of spike trains to the hippocampal CA3 and CA1 data recorded from rats performing a memory-dependent delayed non-match-to-sample (DNMS) task. The regression model is essentially the multiple-input, multiple-output (MIMO) non-linear dynamical model of spike train transformation. It predicts the output spike trains based on the input spike trains and thus restores the output signal. In addition, the classification model interprets the signal by relating the spatio-temporal patterns to the memory events. We have found that: (1) both hippocampal CA3 and CA1 spike trains contain sufficient information for predicting the locations of the sample responses (i.e., left and right memories) during the DNMS task; and more importantly (2) the CA1 spike trains predicted from the CA3 spike trains by the MIMO model also are sufficient for predicting the locations on a single-trial basis. These results show quantitatively that, with a moderate number of unitary recordings from the hippocampus, the MIMO non-linear dynamical model is able to extract and restore spatial memory information for the formation of long-term memories and thus can serve as the computational basis of the hippocampal memory prosthesis.
Related Links	http://dx.doi.org/10.3389/fnsys.2014.00097
Starting Page	97
File Format	PDF
ISSN	16625137
e-ISSN	16625137
Journal	Frontiers in Systems Neuroscience
Volume Number	8
Language	English
Publisher	Frontiers Media S.A.
Publisher Date	2014-05-28
Access Restriction	Open
Rights Holder	Frontiers Media S.A.
Subject Keyword	Research in Higher Education
Content Type	Text
Resource Type	Article
Subject	Cognitive Neuroscience Cellular and Molecular Neuroscience Developmental Neuroscience

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4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
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