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Intra-Arterial Therapy for Acute Ischemic Stroke
| Content Provider | PubMed Central |
|---|---|
| Author | Alex, Abou-chebl |
| Copyright Year | 2013 |
| Abstract | Intra-arterial therapy (IAT) for acute ischemic stroke treatment is evolving. Whereas the efficacy of recanalization with traditional intra-arterial fibrinolysis is relatively poor, mechanically based recanalization with multimodal approaches, stenting and mechanical embolectomy is more effective. Until recently, this has not resulted in overwhelming clinical benefit and has not always equated with reperfusion. The reasons for this are not clearly known but may include inadequate patient selection, poor technique, low operator experience, direct injury from thrombolytics or devices, microvascular occlusions, complications of general anesthesia, or some other unknown factors. Intracerebral hemorrhage still complicates 2-11% of procedures. Large prospective and randomized clinical trials are needed to determine the safety and efficacy of IAT be it pharmacological therapy, embolectomy, stenting, or multimodal therapy. Comparative studies between the newer stent retriever devices and intravenous tissue plasminogen activators may also be needed especially for the 3- to 4.5-hour window. |
| Related Links | http://dx.doi.org/10.1159/000346769 |
| Ending Page | 108 |
| Page Count | 9 |
| Starting Page | 100 |
| File Format | |
| ISSN | 16645545 |
| e-ISSN | 16645545 |
| Journal | Interventional Neurology |
| Issue Number | 2 |
| Volume Number | 1 |
| Language | English |
| Publisher | S. Karger AG |
| Publisher Date | 2013-03-01 |
| Access Restriction | Open |
| Rights Holder | S. Karger AG |
| Subject Keyword | Research in Higher Education |
| Content Type | Text |
| Resource Type | Article |
| Subject | Neurology (clinical) Surgery Cardiology and Cardiovascular Medicine |
