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| Content Provider | PubMed Central |
|---|---|
| Author | Jordan, V. Craig |
| Abstract | Tamoxifen is an unlikely pioneering medicine in medical oncology. Nevertheless, the medicine has continued to surprise us, perform and save lives for the past 40 years. Unlike any other medicine in oncology, it is used to treat all stages of breast cancer, ductal carcinoma in situ, male breast cancer, pioneered the use of chemoprevention by reducing the incidence of breast cancer in women at high risk and induces ovulation in subfertile women! The impact of tamoxifen is ubiquitous. However, the power to save lives from this unlikely success story came from the first laboratory studies which defined that “longer was going to be better” when tamoxifen was being considered as an adjuvant therapy (Jordan 1978 Use of the DMBA-induced rat mammary carcinoma system for the evaluation of tamoxifen as a potential adjuvant therapy Reviews in Endocrine Related Cancer. October Supplement: 49–55.). This is that success story, with a focus on the interdependent components of: excellence in drug discovery, investment in self-selecting young investigators, a conversation with Nature, a conversation between the laboratory and the clinic, and the creation of the Oxford Overview Analysis. Each of these factors was essential to propel the progress of tamoxifen to evolve as an essential part of the fabric of society. “Science is adventure, discovery, new horizons, insight into our world, a means of predicting the future and enormous power to help others”(Hoagland 1990). - Mahlon Hoagland, MD. Director, Worcester Foundation for Experimental Biology (1970–85) |
| Related Links | http://dx.doi.org/10.1530/erc-14-0092 |
| Starting Page | 235 |
| File Format | |
| ISSN | 13510088 |
| e-ISSN | 14796821 |
| Journal | Endocrine-related cancer |
| Issue Number | 3 |
| Volume Number | 21 |
| Language | English |
| Publisher Date | 2014-05-06 |
| Access Restriction | Open |
| Subject Keyword | Cancer Research Oncology Endocrinology, Diabetes and Metabolism Endocrinology Research in Higher Education |
| Content Type | Text |
| Resource Type | Article |
| Subject | Endocrinology, Diabetes and Metabolism Cancer Research Endocrinology Oncology |
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