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| Content Provider | PubMed Central |
|---|---|
| Author | Uphouse, Lynda |
| Copyright Year | 2013 |
| Abstract | In this review, first a historical perspective of serotonin’s (5-HT) involvement in female sexual behavior is presented. Then an overview of studies implicating 5-HT is presented. The effect of drugs that increase or decrease CNS levels of 5-HT is reviewed. Evidence is presented that drugs which increase 5-HT have negative effects on female sexual behavior while a decrease in 5-HT is associated with facilitation of sexual behavior. Studies with compounds that act on 5-HT1, 5-HT2 or 5-HT3 receptors are discussed. Most evidence indicates that 5-HT1A receptor agonists inhibit sexual behavior while 5-HT2 or 5-HT3 receptors may exert a positive influence. There is substantial evidence to support a role for 5-HT in the modulation of female consummatory sexual behavior, but studies on the role of 5-HT in other elements of female sexual behavior (e.g. desire, motivation, sexual appetite) are few. Future studies should be directed at determining if these additional components of female sexual behavior are also modulated by 5-HT. |
| Related Links | http://dx.doi.org/10.1016/j.pbb.2013.11.008 |
| Ending Page | 42 |
| Page Count | 12 |
| Starting Page | 31 |
| File Format | |
| ISSN | 00913057 |
| e-ISSN | 18735177 |
| Journal | Pharmacology, biochemistry, and behavior |
| Volume Number | 0 |
| Language | English |
| Publisher Date | 2014-06-01 |
| Access Restriction | Open |
| Subject Keyword | Toxicology Clinical Biochemistry Biochemistry Biological Psychiatry Behavioral Neuroscience Pharmacology Research in Higher Education |
| Content Type | Text |
| Resource Type | Article |
| Subject | Biological Psychiatry Behavioral Neuroscience Biochemistry Clinical Biochemistry Toxicology Pharmacology |
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