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| Content Provider | PubMed Central |
|---|---|
| Author | Choong, Caroline Victoria Tang, Tiffany Chay, Wen Yee Goh, Christopher Tay, Miah Hiang Zam, Nor Azhari Mohd Tan, Puay Hoon Tan, Min-han |
| Copyright Year | 2011 |
| Abstract | Unusual sites of metastases are recognized in patients with renal cell carcinoma (RCC). However, the prognostic implications of these sites are not well understood. We used the Memorial Sloan-Kettering Cancer Center (MSKCC) risk classification for metastatic RCC to evaluate 912 consecutive patients with RCC managed at the Singapore General Hospital between 1990 and 2009. Among these patients, 301 had metastases either at diagnosis or during the course of illness. Nasal metastases, all arising from clear cell RCC, were identified histologically in 4 patients (1.3% of those with metastasis). All 4 patients were classified as MSKCC poor prognosis by current risk criteria. Nasal metastases were significantly associated with lung and bone metastases. The frequency of nasal metastases in patients with metastatic RCC is about 1 %, occurring predominantly in patients with clear cell RCC. Nasal metastases are associated with poor prognosis as estimated by the MSKCC risk classification, with attendant implications for selection of targeted therapy, and are usually associated with multi -organ dissemination, including concurrent lung and bone involvement. |
| Related Links | http://dx.doi.org/10.5732/cjc.010.10302 |
| Ending Page | 148 |
| Page Count | 5 |
| Starting Page | 144 |
| File Format | |
| ISSN | 1000467X |
| e-ISSN | 1944446X |
| Journal | Chinese Journal of Cancer |
| Issue Number | 2 |
| Volume Number | 30 |
| Language | English |
| Publisher | Sun Yat-sen University Cancer Center |
| Publisher Date | 2011-02-05 |
| Access Restriction | Open |
| Rights Holder | Sun Yat-sen University Cancer Center |
| Subject Keyword | Oncology Research in Higher Education |
| Content Type | Text |
| Resource Type | Article |
| Subject | Oncology |
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