NDLI: Follicular Helper T Cells Promote Liver Pathology in Mice during Schistosoma japonicum Infection

Content Provider	PubMed Central
Author	Chen, Xiaojun Yang, Xiaowei Li, Yong Zhu, Jifeng Zhou, Sha Xu, Zhipeng He, Lei Xue, Xue Zhang, Weiwei Dong, Xiaoxiao Wu, Henry Li, Carrie J. Hsu, Hsiang-ting Kong, Wenjun Liu, Feng Tripathi, Prem B. Yu, Michelle S. Chang, Jason Zhou, Liang Su, Chuan
Editor	Gause, William C.
Copyright Year	2014
Abstract	Following Schistosoma japonicum (S. japonicum) infection, granulomatous responses are induced by parasite eggs trapped in host organs, particular in the liver, during the acute stage of disease. While excessive liver granulomatous responses can lead to more severe fibrosis and circulatory impairment in chronically infected host. However, the exact mechanism of hepatic granuloma formation has remained obscure. In this study, we for the first time showed that follicular helper T (Tfh) cells are recruited to the liver to upregulate hepatic granuloma formation and liver injury in S. japonicum-infected mice, and identified a novel function of macrophages in Tfh cell induction. In addition, our results showed that the generation of Tfh cells driven by macrophages is dependent on cell–cell contact and the level of inducible costimulator ligand (ICOSL) on macrophages which is regulated by CD40–CD40L signaling. Our findings uncovered a previously unappreciated role for Tfh cells in liver pathology caused by S. japonicum infection in mice.
Related Links	http://dx.doi.org/10.1371/journal.ppat.1004097
Starting Page	1004097
File Format	PDF
ISSN	15537374
e-ISSN	15537374
Journal	PLoS Pathogens
Issue Number	5
Volume Number	10
Language	English
Publisher	Public Library of Science
Publisher Date	2014-05-01
Access Restriction	Open
Rights Holder	Public Library of Science
Subject Keyword	Immunology Genetics Molecular Biology Microbiology Parasitology Virology Research in Higher Education
Content Type	Text
Resource Type	Article
Subject	Genetics Virology Molecular Biology Parasitology Immunology Microbiology

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Follicular Helper T Cells Promote Liver Pathology in Mice during Schistosoma japonicum Infection

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