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| Content Provider | PubMed Central |
|---|---|
| Author | Ates, Mehmet Demir, Veysel Arslan, Zikri Daniels, James Farah, Ibrahim O. Bogatu, Corneliu |
| Abstract | In this study, Artemia salina (crustacean filter feeders) larvae were used as a test model to investigate the toxicity of aluminum oxide nanoparticles (Al2O3 NPs) on marine microorganisms. The uptake, toxicity and elimination of α-Al2O3 (50 nm and 3.5 μm) and γ-Al2O3 (5 nm and 0.4 μm) NPs were studied. Twenty-four and ninety-six hour exposures of different concentrations of Al2O3 NPs to Artemia larvae were conducted in a seawater medium. When suspended in water, Al2O3 NPs aggregated substantially with the sizes ranging from 6.3 nm to > 0.3 μm for spherical NPs, and from 250 to 756 nm for rod-shaped NPs. The phase contrast microscope images revealed that NPs deposited inside the guts as aggregates. ICP-MS analysis showed that large particles (3.5 μm α-Al2O3) were not taken up by Artemia, while fine NPs (0.4 μm γ-Al2O3) and ultra-fine NPs (5 nm γ-Al2O3 and 50 nm α-Al2O3) accumulated substantially. Differences in toxicity were detected as changing with NP size and morphology. The malondialdehyde (MDA) levels indicated that smaller γ-Al2O3 (5 nm) NPs were more toxic than larger γ-Al2O3 (0.4 μm) particulates in 96 h. The highest mortality was measured as 34% in 96 h for γ-Al2O3 NPs (5 nm) at 100 mg/L (LC50 > 100 mg/L). γ-Al2O3 NPs were more toxic than α-Al2O3 NPs at in all conditions. |
| Related Links | http://dx.doi.org/10.1002/tox.21917 |
| Ending Page | 118 |
| Page Count | 10 |
| Starting Page | 109 |
| File Format | |
| ISSN | 15204081 |
| e-ISSN | 15227278 |
| Journal | Environmental toxicology |
| Issue Number | 1 |
| Volume Number | 30 |
| Language | English |
| Publisher Date | 2015-01-01 |
| Access Restriction | Open |
| Subject Keyword | Toxicology Health, Toxicology and Mutagenesis Management, Monitoring, Policy and Law Research in Higher Education |
| Content Type | Text |
| Resource Type | Article |
| Subject | Health, Toxicology and Mutagenesis Medicine Toxicology Management, Monitoring, Policy and Law |
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