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| Content Provider | PubMed Central |
|---|---|
| Author | Xu, Yipeng Zhu, Shaoxing Song, Mei Liu, Weihui Liu, Chengyi Li, Yongsheng Wang, Min |
| Copyright Year | 2014 |
| Abstract | The immunological mechanism mediated by T cells is the main therapeutic target in the treatment of renal cell carcinoma (RCC) with interleukin (IL)-2 and interferon (IFN)-α. The aim of the present study was to evaluate the role of B7-H4 in the IL-2, IFN-α and IFN-γ treatment of clear cell RCC (ccRCC). A total of 154 paraffin-embedded ccRCC tissues were studied using immunohistochemistry, which subsequently indicated that positive B7-H4 expression is associated with adverse clinical features in ccRCC. The effects of IL-2, IFN-α and IFN-γ on B7-H4 expression in a ccRCC cell line were evaluated at the mRNA and protein levels. In addition, the effect of B7-H4 on the killing activity of T cells was detected. B7-H4 expression was identified to be upregulated by IL-2, IFN-α and IFN-γ, of which, IFN-γ was the most capable. Additionally, blocking of B7-H4/B7-H4 ligand interactions may rescue the killing activity of T cells. Altogether, the observations of the current study showed that the immune escape pathway induced by B7-H4 may be one of the most important reasons for the low efficacy of IL-2 and IFN-α and the inability to observe the efficacy of IFN-γ in mRCC. This indicates that B7-H4 may be used as a new molecular biology marker to select treatment options for patients with ccRCC. |
| Related Links | http://dx.doi.org/10.3892/ol.2014.1961 |
| Starting Page | 1474 |
| File Format | |
| ISSN | 17921074 |
| e-ISSN | 17921082 |
| Journal | Oncology Letters |
| Issue Number | 5 |
| Volume Number | 7 |
| Language | English |
| Publisher | D.A. Spandidos |
| Publisher Date | 2014-03-01 |
| Access Restriction | Open |
| Rights Holder | D.A. Spandidos |
| Subject Keyword | Cancer Research Oncology Research in Higher Education |
| Content Type | Text |
| Resource Type | Article |
| Subject | Cancer Research Oncology |
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