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| Content Provider | PubMed Central |
|---|---|
| Author | Win, Aung Ko Dowty, James G. Cleary, Sean P. Kim, Hyeja Buchanan, Daniel D. Young, Joanne P. Clendenning, Mark Rosty, Christophe Macinnis, Robert J. Giles, Graham G. Alex, Boussioutas Macrae, Finlay A. Parry, Susan Goldblatt, Jack Baron, John A. Burnett, Terrilea Marchand, Loïc Le Newcomb, Polly A. Haile, Robert W. Hopper, John L. Michelle, Cotterchio Gallinger, Steven Lindor, Noralane M. Tucker, Katherine M. Winship, Ingrid M. Jenkins, Mark A. |
| Copyright Year | 2014 |
| Abstract | We studied 2332 individuals with monoallelic mutations in MUTYH among 9504 relatives of 264 colorectal cancer (CRC) cases with a MUTYH mutation. We estimated CRC risks, through 70 y of age, of 7.2% for male carriers of monoallelic mutations (95% confidence interval [CI], 4.6%–11.3%) and 5.6% for female carriers of monoallelic mutations (95% CI, 3.6%–8.8%), irrespective of family history. For monoallelic MUTYH mutation carriers with a first-degree relative with CRC, diagnosed by 50 y of age who does not have the MUTYH mutation, risks of CRC were 12.5% for men and (95% CI, 8.6%–17.7%) and 10% for women (95% CI, 6.7%–14.4%). Risks of CRC for carriers of monoallelic mutations in MUTYH with a first-degree relative with CRC are sufficiently high to warrant more intensive screening than for the general population. |
| Related Links | http://dx.doi.org/10.1053/j.gastro.2014.01.022 |
| Starting Page | 1208 |
| File Format | |
| ISSN | 15280012 |
| e-ISSN | 15280012 |
| Journal | Gastroenterology |
| Issue Number | 5 |
| Volume Number | 146 |
| Language | English |
| Publisher Date | 2014-05-01 |
| Access Restriction | Open |
| Subject Keyword | Research in Higher Education |
| Content Type | Text |
| Resource Type | Article |
| Subject | Hepatology Gastroenterology |
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