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| Content Provider | PubMed Central |
|---|---|
| Author | Brander, Dm Rizzieri, Da Gockerman, Jp Diehl, Lf Shea, Tc Decastro, Cm Moore, Jo Beaven, Aw |
| Abstract | PTK787/ZK222584 (Vatalanib), an orally active inhibitor of vascular endothelial growth factor receptors (VEGF-Rs), was evaluated in this phase II study of 20 patients with relapsed/refractory diffuse large B-cell lymphoma (DLBCL). Patients received once daily PTK787/ZK222584 at a target dose of 1250mg. Eighteen patients were evaluable for response: 1 patient had a complete response (CR), 6 patients had stable disease but subsequently progressed, 10 patients had progressive disease by 3 cycles, and 1 subject withdrew before response evaluation. The patient who attained a CR underwent autologous stem cell transplantation and remains disease free 76 months after study completion. There were no grade 4 toxicities. Grade 3 thrombocytopenia occurred in 20% and grade 3 hypertension occurred in 10%. There were no episodes of grade 3 proteinuria. In conclusion, PTK787/ZK222584 was well tolerated in a heavily pretreated population of DLBCL patients, though its therapeutic potential as a single agent in DLBCL appears limited. |
| Related Links | http://dx.doi.org/10.3109/10428194.2013.784969 |
| Ending Page | 2630 |
| Page Count | 4 |
| Starting Page | 2627 |
| File Format | |
| ISSN | 10292403 |
| e-ISSN | 10292403 |
| Journal | Leukemia & lymphoma |
| Issue Number | 12 |
| Volume Number | 54 |
| Language | English |
| Publisher Date | 2013-12-01 |
| Access Restriction | Open |
| Subject Keyword | Research in Higher Education |
| Content Type | Text |
| Resource Type | Article |
| Subject | Hematology Cancer Research Oncology |
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